SIA (N-Succinimidyl iodoacetate)

Supplier: Thermo Fisher Scientific
Warning

Synonyms: 2,5-Dioxopyrrolidin-1-yl 2-iodoacetate, N-Succinimidyl iodoacetate, Iodoacetic acid N-succinimidyl Ester, N-(Iodoacetoxy)succinimide, SIA

22349
PIER22349EA 91 EUR
PIER22349
SIA (N-Succinimidyl iodoacetate)
SIA (N-Succinimidyl iodoacetate)

Thermo Scientific Pierce SIA is a very short (1.5 angstrom) crosslinker for amine-to-sulfhydryl conjugation via N-hydroxysuccinimide (NHS) ester and iodoacetyl reactive groups.


  • Reactive groups: NHS ester and iodoacetyl
  • Reactive toward: amino and sulfhydryl groups
  • Shortest sulfhydryl-reactive and amine-reactive heterobifunctional crosslinker available; compare to SIAB
  • NHS ester reacts with primary amines at pH 7-9 to form a stable amide bond
  • Iodoacetyl group reacts with sulfhydryl groups at pH > 7.5 to form stable thioether bond
  • Non-cleavable
  • Water-insoluble (dissolve first in DMF or DMSO)


Caution: For Research Use Only. Not for use in diagnostic procedures.

Formula: C₆H₆INO₄
MW: 283.02 g/mol
Storage Temperature: Refrigerator
MDL Number: MFCD00058451
CAS Number: 39028-27-8

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