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When a solvent is pumped through columns featuring a pre-packed flash chromatography sorbent bed, the sample mixture compounds separate. Compound molecules with a charge affinity similar to the stationary phase sorbent are absorbed, allowing researchers to isolate, identify, and purify a substance. Quicker than conventional liquid methods, the flash chromatography sorbents have throughput efficiency and moderate resolution. Since the particle size affects how the solvent flows through the column, sorbents are offered in different sizes.