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Supplier: ENZO LIFE SCIENCES AG
Description: Macrocyclic-triene antibiotic possessing potent immunosuppressant activity. It forms a complex with FKBP12 that binds to an effector, thus inhibiting IL-2 and other growth promoting lymphokines. The effectors were identified as FRAP (FKBP12 rapamycin-associated protein) and RAFT1 (rapamycin and KFBP12 target). rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. rapamycin induces inhibition of p70<sup>s6k</sup>, p33<sup>cdk2</sup> and p34<sup>cdc2</sup>. Selectively blocks signaling leading to the activation of p70/85 S6 kinase. Enhances apoptosis. Activator of autophagy both<i> in vitro</i> and <i>in vivo</i>.

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Supplier: Apollo Scientific
Description: Macrocyclic triene antibiotic.

Supplier: Thermo Scientific
Description: Rapamycin ≥99%
Supplier: MP Biomedicals
Description: Rapamycin binds to and inhibits the molecular target of Rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of Rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has anticancer activity.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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