Resin, PL-CMS, StratoSpheres™

Supplier: VARIAN

PL1461-4799 PL1461-6749 PL1461-6769 PL1461-6799
VARIPL1461-4799EA 276 EUR
VARIPL1461-4799 VARIPL1461-6749 VARIPL1461-6769 VARIPL1461-6799
Resin, PL-CMS, StratoSpheres™
Chromatography Sorbents SPE Sorbents

Chloromethylpolystyrene known as merrifield resin, PL-CMS is a copolymer support for solid phase synthesis of peptides using Boc chemistry.


Boc-amino acids are typically attached to the resin as a cesium salt, although other techniques have also been used. A slight excess of acid is neutralized with cesium carbonate and the activated acid isolated by evaporation.


Other useful techniques for cleavage include saponification or hydrolysis to create free acids, trans-esterification to create methyl esters, or aminolysis to form carboxamides. PL-CMS can be used to generate a variety of other supports by the attachment of appropriate linkers, particularly through Williamson ether synthesis.

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