Anti-CCND1 Mouse Monoclonal Antibody (Purified) [clone: DCS-6]

Supplier: Biotium
BNUB0007-500 BNUB0007-100
BNUB0007-500EA 511 EUR
BNUB0007-500 BNUB0007-100
Anti-CCND1 Mouse Monoclonal Antibody (Purified) [clone: DCS-6]
Antibodies
Recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

Type: Primary
Antigen: CCND1
Clonality: Monoclonal
Clone: DCS-6
Conjugation: Purified
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Human, Monkey, Mouse, Rat
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