Anti-MVP Mouse Monoclonal Antibody (CF640R) [clone: 1014]

Supplier: Biotium
BNC400224-500 BNC400224-100
BNC400224-500EA 560 EUR
BNC400224-500 BNC400224-100
Anti-MVP Mouse Monoclonal Antibody (CF640R) [clone: 1014]
Antibodies
Recognizes a protein of 104 kDa-110 kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.

Type: Primary
Antigen: MVP
Clonality: Monoclonal
Clone: 1014
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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