BQCA ≥98%, crystalline

Supplier: Cayman Chemical

Synonyms: 1-(4-Methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Benzyl quinolone carboxylic acid.

15393-10 15393-5 15393-25 15393-50
CAYM15393-10EA 157 EUR
CAYM15393-10 CAYM15393-5 CAYM15393-25 CAYM15393-50
BQCA ≥98%, crystalline
BQCA

BQCA is a highly selective positive allosteric modulator of the M₁ muscarinic acetylcholine receptor (mAChR), as it dose-dependently reduces the concentration of acetylcholine required to activate the M₁ receptor. The effective range for potentiation of M₁ in cells by BQCA is 0,1 to 100 μM with an inflection point value of 845 nM when 3 nM acetylcholine is used.


BQCA displays no potentiation, agonism, or antagonism at other mAChRs at concentrations up to 100 μM. It has excellent brain penetration and increases the firing rate of medial prefrontal cortex neurons in vivo in rats. BQCA prevents scopolamine-induced memory deficits in both contextual fear conditioning and a spontaneous alternation task in mice. It also restores impairment in reversal learning in a mouse model of Alzheimer’s disease and improves memory performance in rats.

Formula: C₁₈H₁₅NO₄
MW: 309,3 g/mol
MDL Number: MFCD01315710
CAS Number: 338747-41-4

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Specification Test Results

Purity ≥98%
Formulation A crystalline solid
λmax 224, 315, 328 nm
Storage –20 °C
Stability ≥2 years

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