Mouse Recombinant PDGF-BB (from E. coli)
Supplier: Shenandoah Biotechnology
Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis.
- Produced from genetically modified E. coli
- Dimeric protein contains 110/220 amino acids
- Binds the cell surface receptor tyrosine kinases PDGFR-a and PDGFR-b
PDGF synthesis is induced by interleukin 1 (IL-1), interleukin 6 (IL-6), tumor necrosis factor alpha (TNFα), transforming growth factor beta (TGF-β), and epidermal growth factor (EGF) signaling.
This functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells. It is also stored in the alpha-granules of platelets and is released upon adherence to traumatized tissues.
This dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB).
Delivery information: A certificate of analysis (COA) is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions.
Caution: This product is for research use only and is not for use in humans.
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