DSG (Disuccinimidyl glutarate), Pierce™

Supplier: Thermo Fisher Scientific

Synonyms: Di(N-succinimidyl) glutarate, Bis(2,5-dioxopyrrolidin-1-yl) glutarate, DSG Crosslinker, DSG

20593 A35392
PIER20593EA 148 EUR
PIER20593 PIERA35392
DSG (Disuccinimidyl glutarate), Pierce™
DSG (Disuccinimidyl glutarate)

Thermo Scientific Pierce DSG is a water-insoluble, homo-bifunctional N-hydroxysuccinimide ester (NHS-ester) crosslinker often used for conjugating radiolabeled ligands to cell-surface receptors. The NHS ester is the simplest and most commonly used reactive group for crosslinking and labeling proteins and peptides. NHS esters react with primary amines on the N-termini of peptides and the  amine of lysine residues, forming a stable, covalent amide bond and releasing the NHS group.


  • Reactive groups: NHS ester (both ends)
  • Reactive towards: amino groups (primary amines)
  • Non-cleavable
  • Water-insoluble (dissolve first in DMF or DMSO)
  • Membrane-permeable, allowing for intracellular crosslinking
  • Can increase crosslinking efficiency compared to DSS in some applications


Thermo Scientific No-Weigh products are specialty reagents provided in a pre-aliquoted format. The pre-weighed packaging prevents the loss of reagent reactivity and contamination over time by eliminating the repetitive opening and closing of the vial. The format enables use of a fresh vial of reagent each time, eliminating the hassle of weighing small amounts of reagents and reducing concerns over reagent stability.


Caution: For Research Use Only. Not for use in diagnostic procedures.

Formula: C₁₃H₁₄N₂O₈
MW: 326,26 g/mol
Storage Temperature: Refrigerator
MDL Number: MFCD00153597
CAS Number: 79642-50-5

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Specification Test Results

Product Line Pierce™
Labeling Method Chemical Labeling
Crosslinker Type Homobifunctional
Reactive Moiety NHS Ester
Spacer Short
Form Powder
Quantity 50 mg/10 x 1 mg
Type Crosslinker
Solubility DMF, DMSO

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