5-Fluorouracil ≥99% (by HPLC), powder, Sigma-Aldrich®
Supplier: SIGMA-ALDRICH MICROSCOPY
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Danger
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Synonyms:
Fluorouracil, 5-Fluoropyrimidine-2,4(1H,3H)-dione, 5-FU
M-Clarity™ quality level = MQ200
5-Fluorouracil has been used to induce apoptosis in cells. It has been used as a chemosensitising agent. A potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase, thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.
Formula:
C₄H₃FN₂O₂ MW: 130,08 g/mol Boiling Pt: 347 °C (1013 hPa) Melting Pt: 282…286 °C (dec., lit.) Storage Temperature: RT |
MDL Number:
MFCD00006018 CAS Number: 51-21-8 EINECS: 200-085-6 UN: 2811 ADR: 6.1,III Merck Index: 13,04208 |
Specification Test Results
Appearance (Colour) | White to Off-White |
Appearance (Form) | Powder |
Solubility (Colour) | Colourless to Very Faint Yellow |
Solubility (Turbidity), 50 mg per ml in 1 M Ammonium Hydroxide | Clear |
Infrared spectrum | Conforms to Structure |
Purity (HPLC) | ≥99% |
Recommended Retest Period | 2 years |
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