Anti-CD25 Rat Monoclonal Antibody [clone: PC61.5] (PE)

Supplier: STEMCELL Technologies
60009PE 60009PE.1
STMC60009PEEA 367 EUR
STMC60009PE STMC60009PE.1
Anti-CD25 Rat Monoclonal Antibody [clone: PC61.5] (PE)
Antibodies
Rat monoclonal IgG1 antibody against mouse CD25, PE-conjugated.

  • T cells
  • T cells regulatory

The PC61.5 antibody reacts with mouse CD25 (low-affinity interleukin‐2 receptor α chain or IL-2Rα), which is an ~55 kDa type 1 transmembrane glycoprotein expressed on T and B cell progenitors, activated (but not resting) T and B cells, regulatory T (Treg) cells, dendritic cells, and activated monocytes and macrophages. Expression of CD25, together with CD4 and FOXP3, is considered a phenotypic signature for Treg cells. CD25 per se has low affinity for its IL-2 ligand but associates with CD122 (IL-2Rβ) and CD132 (IL-2Rγ) to form the high-affinity IL-2R receptor. CD25 is necessary for receptor clustering and induction of signaling pathways involved in the activation and proliferation of lymphocytes. Binding of the PC61.5 antibody inhibits binding of IL-2 to the low- and high-affinity receptors, which may result in inhibition of IL-2-dependent proliferation. The epitope recognized by PC61.5 is distinct from the IL-2 binding site and from the epitopes recognized by antibodies 7D4 and 3C7.

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD25
Clonality: Monoclonal
Clone: PC61.5
Conjugation: PE
Epitope:
Host: Rat
Isotype: IgG1 lambda
Reactivity: Mouse
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