Anti-CD45RA Mouse Monoclonal Antibody [clone: HI100] (PE)

Supplier: STEMCELL Technologies
100-0319 100-0320
STMC100-0319EA 166 EUR
STMC100-0319 STMC100-0320
Anti-CD45RA Mouse Monoclonal Antibody [clone: HI100] (PE)
Antibodies
Mouse monoclonal IgG2b, antibody against human, chimpanzee, CD45RA, Biotin-conjugated.

  • Granulocytes
  • Subsets
  • Hematopoietic Stem
  • Progenitor cells
  • Leukocytes
  • Lymphocytes

The HI100 antibody reacts with an extracellular epitope on the CD45RA isoform of CD45, a type I transmembrane glycoprotein and member of the protein tyrosine phosphatase family (receptor class 1/6 subfamily). Alternative splicing of exons 4, 5, and 6 that encode the extracellular RA, RB, and RC polypeptides of CD45 gives rise to several isoforms with molecular masses of 180 - 240 kDa. Excision of exon 4 generates the ~220-kDa CD45RA isoform, which is expressed on naïve T cells, subsets of B cells and monocytes, and medullary thymocytes. CD45RA functions to enhance signaling through both the T cell receptor and B cell receptor. The HI100 antibody is commonly used in combination with antibodies against the CD45RO isoform to discern naïve and memory T cells and is useful for identifying the suppressor/inducer subset of CD4+ lymphocytes. The proportion of CD45RA+ T cells typically decreases with age.

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD45RA
Clonality: Monoclonal
Clone: HI100
Conjugation: PE
Epitope:
Host: Mouse
Isotype:
Reactivity: Chimpanzee;Human
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