Anti-CD68 Mouse Monoclonal Antibody [clone: Y1/82A] (Alexa Fluor® 488)

Supplier: STEMCELL Technologies
60105AD 60105AD.1
STMC60105ADEA 596 EUR
STMC60105AD STMC60105AD.1
Anti-CD68 Mouse Monoclonal Antibody [clone: Y1/82A] (Alexa Fluor® 488)
Antibodies
Mouse monoclonal IgG2b antibody against human CD68, Alexa Fluor® 488-conjugated.

  • Granulocytes
  • Subsets
  • Myeloid cells

The Y1/82A antibody reacts with human CD68, an ~110 kDa type 1 transmembrane glycoprotein and member of the sialomucin, LAMP and scavenger receptor families. The heavily glycosylated extracellular domain of CD68, which contains a praline-rich spacer region separating mucin and LAMP domains, binds low-density lipoprotein and certain lectins and selectins, though the function of CD68 remains unclear. CD68 is highly expressed in lysosomes, endosomes and cytoplasmic granules, and more weakly on the surface of macrophages, monocytes, neutrophils, basophils, dendritic cells and NK cells. It has also been detected in the cytoplasm of γ/δ T cells, LAK cells, fibroblasts, endothelial cells and subsets of B cells and hematopoietic progenitors, as well as in various non-hematopoietic tissues such as liver and kidney. The Y1/82A antibody recognizes an epitope distinct from those of antibody clones Y2/131, EBM11, Ki-M6 and KP1. Y1/82A is reportedly more specific for monocytes and macrophages than KP1.

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD68
Clonality: Monoclonal
Clone: Y1/82A
Conjugation: Alexa Fluor® 488
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human
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