Tris(hydroxymethyl)aminomethane (TRIS, Trometamol) 99.0-100.5% Ph. Eur., USP
Supplier: VWR Chemicals
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Warning
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87020.290EA
362
EUR
87020.290
87020.360
87020.460
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol) 99.0-100.5% Ph. Eur., USP
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol)
Appearance: White or almost white, crystalline powder or colourless crystals.
Residues of metal catalysts or reagents: Conforms to EMEA/CHMP/SWP/4446/2000
Caution: Not for use as Active Pharmaceutical Ingredient (API)
Formula:
NH₂C(CH₂OH)₃ Boiling Pt: 357 °C (1013 hPa) Melting Pt: 169…172 °C Density: 1,328 g/cm³ (20 °C) Storage Temperature: Ambient |
MDL Number:
MFCD00004679 CAS Number: 77-86-1 EINECS: 201-064-4 Merck Index: 13,09842 |
Specification Test Results
Appearance | Conforms (see CoA/CoS) |
Heavy metals (as Pb) | Max. 10 ppm |
Residual solvents Class 2 (ICH Q3C) : | Passes test USP |
Methanol | Below option 1 limit |
Other residual solvents(Ph.Eur./ICH) | Unlikely by manuf.process |
Residues of metal catalysts or reagents | Unlikely by manuf.process |
As (Arsenic) | Max. 2 ppm |
Cd (Cadmium) | Max. 1 ppm |
Co (Cobalt) | Max. 1 ppm |
Hg (Mercury) | Max. 2 ppm |
Ni (Nickel) | Max. 50 ppm |
Pb (Lead) | Max. 3 ppm |
V (Vanadium) | Max. 2 ppm |
Conforms to Ph.Eur./USP | Passes test |
Ph.Eur. specifications: | Max. 0.1 % |
Assay (calculated on dried) [Ph.Eur.] | 99.0 --> 100.5 % |
Identification B [Ph.Eur.] | 168 --> 174 °C |
Identification C | Passes test USP |
Appearance of solution | Passes test Ph.Eur. |
pH (20°C; 5 %) [Ph.Eur.] | 10.0 --> 11.5 |
Related substances [Ph.Eur.] | Max. 1.0 % |
Cl (Chloride) [Ph.Eur.] | Max. 100 ppm |
Fe (Iron) [Ph.Eur.] | Max. 10 ppm |
Loss on drying (105°C) [Ph.Eur.] | Max. 0.5 % |
Sulphated ash [Ph.Eur.] | Max. 0.1 % |
USP specifications: | |
Assay (calculated on dried basis) [USP] | 99.0 --> 101.0 % |
Identification A | Passes test USP |
Identification B | Passes test USP |
Residue on ignition [USP] | Max. 0.1 % |
Melting range or temperature [USP] | 168 --> 172 °C |
pH (5 %) [USP] | 10.0 --> 11.5 |
Loss on drying (105°C; 3 h) [USP] | Max. 1.0 % |
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