Hydrophobic interaction chromatography resins, Toyopearl®, TSK-GEL®

Supplier: TOSOH Bioscience

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TOYO0007476EA 880 EUR
TOYO0007476 TOYO0007477 TOYO0007478 TOYO0014477 TOYO0014478 TOYO0014479 TOYO0014701 TOYO0014718 TOYO0014720 TOYO0016050 TOYO0016052 TOYO0016172 TOYO0016173 TOYO0019026 TOYO0043151 TOYO0043152 TOYO0043153 TOYO0043176 TOYO0043177 TOYO0043276 TOYO0043277 TOYO0019818 TOYO0044465 TOYO0014703 TOYO0019956 TOYO0021448 TOYO0021888 TOYO0043126 TOYO0019027 TOYO0019955 TOYO0019957 TOYO0016174 TOYO0014783 TOYO0014784 TOYO0014785 TOYO0016175 TOYO0043127 TOYO0021449 TOYO0021450 TOYO0021889 TOYO0021887 TOYO0019802 TOYO0021301
Hydrophobic interaction chromatography resins, Toyopearl®, TSK-GEL®
Chromatography Sorbents HPLC Sorbents

Hydrophobic interaction chromatography (HIC) is a powerful tool for the process purification of biomolecules. Five HIC ligands featuring different degrees of hydrophobicity and selectivity. The hydrophobicity of HIC resins increases through the ligand series.


  • Typically used in intermediate purification and polishing steps


Ether HIC resins: Ether hydrophobic interaction chromatography (HIC) resins have the highest hydrophilicity (lowest hydrophobicity) of the HIC ligands. The ether ligand is useful for very hydrophobic molecules such as membrane proteins. It is typically used in intermediate purification and polishing steps.


Phenyl HIC resins: Phenyl hydrophobic interaction chromatography resins are in the middle of the hydrophobicity range. Primary applications are for the separation of proteins, their isoforms, and aggregate removal.


Butyl HIC resins: Butyl hydrophobic interaction chromatography (HIC) resins have the second highest hydrophobicity of the HIC ligands. There are three pore sizes available for this ligand and each has been optimised for a specific molecular size profile. The primary applications are the separation of proteins, their isoforms, and aggregate removal.


Hexyl HIC resins: Hexyl hydrophobic interaction chromatography (HIC) resin has the highest hydrophobicity of the HIC ligands. It is used for very hydrophilic proteins or where a low salt elution environment is required.

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