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Description: The 70 kDa heat shock protein Hsp70 belongs to the Hsp70 family of highly-related protein isoforms ranging in size from 66 kDa to 78 kDa. Hsc70 shares close biochemical and biological ties to Hsp70, and also belongs to the Hsp70 family. These proteins include cognate members found within major intracellular compartments and highly inducible isoforms predominantly cytoplasmic or nuclear in distribution. Members of the Hsp70 family function as molecular chaperones involved in such cellular functions as protein folding, transport, maturation and degradation, operating in an ATP-dependent manner. The molecular chaperones of the Hsp70 family recognize and bind to nascent polypeptide chains or partially folded intermediates of proteins, preventing their aggregation and misfolding, and the binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein. Data demonstrates that with a ubiquitin-like domain at its amino terminus and its association with the 26S proteosome in HeLa cells, Bag-1 modulates the chaperone activity of Hsc70 and Hsp70. These findings reveal Bag-1's role as a physical link between the Hsc70/Hsp70 chaperone system and the proteasome. Experimental data also shows that the ATPase domain and the substrate binding domain of Hsp70 (or Hsc70) cooperate to form a co-chaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp), essential for normal neurotransmitter release.
Catalog Number: ENZOADISPA8136D
UOM: 1 * 50 µG
Supplier: ENZO LIFE SCIENCES


Description: These temperature resistant knitted gloves made of synthetic Thermolite® fibres are ideal for non sterile and dry food handlings in refrigerated or chilled conditions.
Catalog Number: 112-0151
UOM: 1 * 1 PAIR
Supplier: Ansell


Description: Sterilized LDPE cytostatic protective packaging for transport, storage, patient transfer and internal sterile transport.
Catalog Number: KWPA2.100.081
UOM: 1 * 20 items
Supplier: KWP KUNSTSTOFF WERK PLUR

Description: This knitted spandex/nylon/Dyneema® glove with thin PU palm coating provides a high level of dexterity and tactility for applications with cut risks.
Catalog Number: 112-2726
UOM: 1 * 12 PAIR
Supplier: Ansell


Description: These high strength bags, made from PP, are ideal for hazardous waste collection and decontamination in an autoclave. Bags are formulated to withstand stress at the side seams and are strong enough to hold items in the laboratory. They are red and printed with a black biohazard symbol: 'Infectious Waste' and feature a temperature indicator patch.
Catalog Number: 129-0222
UOM: 1 * 400 items
Supplier: VWR Collection


Description: These ¾ nitrile coated gloves with cotton jersey lining offer good resistance to abrasive materials.
Catalog Number: ANSE48-913/9
UOM: 1 * 12 PAIR
Supplier: Ansell


Description: This industrial work nylon glove with nitrile palm coating provides light mechanical protection with dexterity. Designed specifically for use in moderately oily manufacturing and maintenance environments.
Catalog Number: ANSE11-900/6
UOM: 1 * 12 PAIR
Supplier: Ansell


Description: Tubular LDPE 80 µ pouches - pharma quality.
Catalog Number: CDPA7402868
UOM: 1 * 1.600 items
Supplier: S▄DPACK MEDICA

Certificates New Product


Description: PS. These dishes for microbiology application are manufactured under strict aseptic conditions using on-line production and packaging (ISO 6).
Catalog Number: 391-0603
UOM: 1 * 720 items
Supplier: VWR Collection


Description: PP with HDPE screw cap.
Catalog Number: 525-0384
UOM: 1 * 500 items
Supplier: Greiner Bio-One

Description: These natural rubber gloves deliver excellent sensitivity combined with superior tensile strength.
Catalog Number: ANSE87-665/7.5-8
UOM: 1 * 1 PAIR
Supplier: Ansell


Description: The 70 kDa heat shock protein Hsp70 belongs to the Hsp70 family of highly-related protein isoforms ranging in size from 66 kDa to 78 kDa. Hsc70 shares close biochemical and biological ties to Hsp70, and also belongs to the Hsp70 family. These proteins include cognate members found within major intracellular compartments and highly inducible isoforms predominantly cytoplasmic or nuclear in distribution. Members of the Hsp70 family function as molecular chaperones involved in such cellular functions as protein folding, transport, maturation and degradation, operating in an ATP-dependent manner. The molecular chaperones of the Hsp70 family recognize and bind to nascent polypeptide chains or partially folded intermediates of proteins, preventing their aggregation and misfolding, and the binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein. Data demonstrates that with a ubiquitin-like domain at its amino terminus and its association with the 26S proteosome in HeLa cells, Bag-1 modulates the chaperone activity of Hsc70 and Hsp70. These findings reveal Bag-1's role as a physical link between the Hsc70/Hsp70 chaperone system and the proteasome. Experimental data also shows that the ATPase domain and the substrate-binding domain of Hsp70 (or Hsc70) cooperate to form a co-chaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp), essential for normal neurotransmitter release.
Catalog Number: ENZOADISPA8132D
UOM: 1 * 50 µG
Supplier: ENZO LIFE SCIENCES


Description: Processed in a controlled environment, tapes are wound on a plastic core and single bagged. Ideal for wheel taping and colour coding applications such as spray bottle identification.
Catalog Number: 817-0254
UOM: 1 * 1 Roll
Supplier: MICRONOVA


Description: These heavy duty gloves consist of two layers: The soft inner layer is made of acrylic terry and the 3/4 nitrile coating provides comfort and dexterity.
Catalog Number: 112-5060
UOM: 1 * 6 PAIR
Supplier: Ansell


Description: The unique LDPE/nylon laminate is a good barrier material for transporting raw materials or to line buckets containing disinfectants or other cleaning solutions.
Catalog Number: MICRBKL-2430IR
UOM: 1 * 24 items
Supplier: MICRONOVA


Description: Hard to pierce pouch offering protection against the danger of being cut by contaminated sharp objects. Convenient for labs, clinics and medical offices. Used with the Poxygrid® safety pouch stand for easy benchtop collection.
Catalog Number: BELAH132340000
UOM: 1 * 200 items
Supplier: Bel-Art Products, a Part of SP


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