You Searched For: Amberlite\u00AE+IRC-748

Supplier: Thermo Fisher Scientific

Description: Achieve fast, high-resolution separations at low backpressures using Thermo Scientific™ Accucore C18 columns.

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Catalog Number: (BOSSBS-5785R-A750)

Supplier: Bioss

Description: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organisation. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibres and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-5785R-A680)

Supplier: Bioss

Description: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organisation. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibres and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.

UOM: 1 * 100 µl

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Supplier: 3M

Description: The Versaflo™ powered air Turbo TR-600 is a belt-mounted air purifying device. When combined with one of the 3M approved helmets, it forms a power-assisted system for respiratory protection against particles, nuisance odours (where applicable) and gases and vapours.

Supplier: Thermo Fisher Scientific

Description: These columns offer enhanced retention of polar and hydrophilic analytes. Based on Core Enhanced Technology, they provide fast, high resolution separations without the elevated back pressures required by sub-2 µm particles.

Catalog Number: (MLDVIXHCSAIADV)

Supplier: Molecular Devices

Description: <p>The ImageXpress® HCS.ai High-Content Screening System captures your imagination with high-quality imaging and analysis, enabling you to acquire the data you need with ease.</p>

UOM: 1 * 1 items

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Catalog Number: (BOSSBS-11083R-A680)

Supplier: Bioss

Description: Junctophilins are components of the junctional complexes between plasma membranes and endoplasmic or sarcoplasmic reticulums present in all excitable cells. Junctophilins contain a cytoplasmic domain which binds to the plasma membrane, as well as an ER/SR membrane spanning hydrophobic C-terminal segment. The three subtypes in this family are Junctophilin-1, -2 and -3. Junctophilin-1 is predominantly expressed in skeletal muscle, but is also expressed at low levels in heart. Junctophilin-2 is expressed in heart and skeletal muscle. Mutant mice lacking the Jph2 gene exhibit embryonic lethality and possess cardiac myocytes that express abnormal calcium transients. Junctophilin-3 is expressed in brain. The JPH3 alternatively spliced exon 2A has been suggested as a site for CTG repeat expansion leading to a Huntington disease-like autosomal dominant disorder.

UOM: 1 * 100 µl

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Catalog Number: (ANTIA313967-96)

Supplier: ANTIBODIES.COM

Description: Human ZIP-3 ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of human ZIP-3 in serum, plasma, and other biological fluids.

UOM: 1 * 96 Tests

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Supplier: Thermo Fisher Scientific

Description: These columns offer a high shape selectivity for hydrophobic, long chain, structurally-related isomers. Based on Core Enhanced Technology, they provide fast, high resolution separations without the elevated back pressures required by sub-2 µm particles.

Supplier: Thermo Fisher Scientific

Description: Contains a C4 linker which allows for superior alignment of the phenyl ring with aromatic molecules. Get excellent retention and unique selectivity for aromatic and moderately polar analytes with Thermo Scientific™ Hypersil GOLD™ Phenyl reversed phase HPLC columns.

Catalog Number: (554-2329)

Supplier: Thermo Fisher Scientific

Description: These columns offer a unique HILIC selectivity and low ion exchange activity. Based on Core Enhanced Technology, they provide fast, high resolution separations without the elevated back pressures required by sub-2 µm particles.

UOM: 1 * 1 items

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Catalog Number: (BOSSBS-11083R-A750)

Supplier: Bioss

Description: Junctophilins are components of the junctional complexes between plasma membranes and endoplasmic or sarcoplasmic reticulums present in all excitable cells. Junctophilins contain a cytoplasmic domain which binds to the plasma membrane, as well as an ER/SR membrane spanning hydrophobic C-terminal segment. The three subtypes in this family are Junctophilin-1, -2 and -3. Junctophilin-1 is predominantly expressed in skeletal muscle, but is also expressed at low levels in heart. Junctophilin-2 is expressed in heart and skeletal muscle. Mutant mice lacking the Jph2 gene exhibit embryonic lethality and possess cardiac myocytes that express abnormal calcium transients. Junctophilin-3 is expressed in brain. The JPH3 alternatively spliced exon 2A has been suggested as a site for CTG repeat expansion leading to a Huntington disease-like autosomal dominant disorder.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-4056R-A750)

Supplier: Bioss

Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-4056R-A680)

Supplier: Bioss

Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-3574R-A680)

Supplier: Bioss

Description: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

UOM: 1 * 100 µl

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Catalog Number: (ANTIA310172-96)

Supplier: ANTIBODIES.COM

Description: Human TNFAIP3 ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of human TNFAIP3 in serum, plasma, and other biological fluids.

UOM: 1 * 96 Tests

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