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Image Unavailable-BOSSBS-11830R-CY3

Anti-CA10 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-11830R-CY3)
Supplier: Bioss
Description: Carbonic anhydrases (CAs) are members of a large family of zinc metalloenzymes responsible for catalyzing the reversible hydration of carbon dioxide. CAs show extensive diversity in their distribution and subcellular localization. They are involved in a variety of biological processes, including calcification, bone resorption, respiration, acid-base balance and the formation of aqueous humor, saliva, gastric juice and cerebrospinal fluid. CA X also referred to as Carbonic anhydrase-related protein X (CA-RP X) or Cerebral protein 15, is a member of the carbonic anhydrase family that lacks two of the three Zn-binding motifs essential for carbonic anhydrase activity. For this reason, CA X does not exhibit catalytic activity. It is expressed primarily in brain and kidney and may play a role in brain development.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12274R-A680

Anti-OVOL2/ZNF339 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-12274R-A680)
Supplier: Bioss
Description: The Ovo family of zinc-finger transcription factors encode evolutionarily conserved genes including those from Caenorhabditis elegans, Drosophila melanogaster, mouse and human. Members of the Ovo family include Ovol1 and Ovol2. Ovol1 acts as a transcriptional repressor by interacting with key developmental Signalling pathways such as Wnt and TGF-/BMP. Specifically, Ovol1 represses c-Myc and Id2 genes and establishes a balance between proliferation and differentiation of progenitor cells. Deletion of Ovol1 in mice leads to germ cell degeneration and defective sperm production in adult males. Ovol1 has also been shown to repress itself as well as Ovol2, which is thought to regulate neural development and vascular angiogenesis during embryogenesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12274R-A750

Anti-OVOL2/ZNF339 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-12274R-A750)
Supplier: Bioss
Description: The Ovo family of zinc-finger transcription factors encode evolutionarily conserved genes including those from Caenorhabditis elegans, Drosophila melanogaster, mouse and human. Members of the Ovo family include Ovol1 and Ovol2. Ovol1 acts as a transcriptional repressor by interacting with key developmental Signalling pathways such as Wnt and TGF-/BMP. Specifically, Ovol1 represses c-Myc and Id2 genes and establishes a balance between proliferation and differentiation of progenitor cells. Deletion of Ovol1 in mice leads to germ cell degeneration and defective sperm production in adult males. Ovol1 has also been shown to repress itself as well as Ovol2, which is thought to regulate neural development and vascular angiogenesis during embryogenesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11677R

Anti-UCHL1+3 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-11677R)
Supplier: Bioss
Description: The two ubiquitin C-terminal hydrolase (UCH) enzymes, UCHL1 and UCHL3, deubiquitinate ubiquitin-protein conjugates and control the cellular balance of ubiquitin. UCHL1 and UCHL3 are both small proteins of ~220 amino acids that share more than 40% amino acid sequence identity. UCHL3 is universally expressed in all tissues, while UCHL1 is expressed exclusively in neuronal tissue, testis and ovary. The activity of UCHL3 is more than 200 fold higher than UCHL1 when a fluorogenic ubiquitin substrate is used. UCHL1 associates with monoubiquitin and UCHL3 binds to Nedd8, ubiquitin-like protein. UCHL1 and UCHL3 play a role in the regulation of neuronal development and spermatogenesis. UCHL1 is involved in the pathogenesis of Parkinson’s disease (PD) and Alzheimer’s disease (AD).
UOM: 1 * 100 µl
Product Image-512-3301

Vacuum filter holders, stainless steel

Supplier: Sartorius
Description: For colony counting and particle collection, specially designed for applications in which the particles or microorganisms retained on the membrane filter surface are of interest. The stainless steel frit filter support ensures a uniform distribution of the residues.

Product Image-512-4518

Membrane filters, type 111

Supplier: Sartorius
Description: Cellulose acetate hydrophilic membrane filters. Ideal for biological and clinical analysis, sterility tests and scintillation measurements. Very low protein binding capacity, suitable for aqueous, alcoholic media and hot gases.

Certificates

Product Image-SART1757H-K

Syringe filters, Minisart® PES

Supplier: Sartorius
Description: Minisart® PES with polyethersulfone (PES) is optimal for highest flow rates and a pH of 2 - 13. Type 1776D with a pore size of 0,22 µm can be used for sterile filtration and has a male Luer slip outlet. Version ACK is individually packed and sterilised by ethylene oxide (EO).

Image Unavailable-BOSSBS-2912R-FITC

Anti-MAP1A/MAP1B LC3 A/B Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-2912R-FITC)
Supplier: Bioss
Description: A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11349R-A680

Anti-ICA1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-11349R-A680)
Supplier: Bioss
Description: Carbonic anhydrases (CAs), also designated carbonate dehydratases or carbonate hydrolyases, form a large family of genes that encode zinc metalloenzymes of great physiologic importance. As catalysts of the reversible hydration of carbon dioxide, these enzymes participate in a variety of biologic processes, including respiration, acid-base balance, bone resorption and calcification as well as the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. Genes in the carbonic anhydrase family encode either active carbonic anhydrase isozymes or _catalytic?(devoid of CO2 hydration activity) carbonic anhydrase-related proteins. Human CA I (CA1) is encoded by the CA1 gene, which maps to a region on chromosome 8 that harbors a cluster of CA genes. CA I localizes to the cytoplasm and research indicates that a severe deficiency of CA I does not result in any obvious hematological or renal consequences.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11349R-A555

Anti-ICA1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-11349R-A555)
Supplier: Bioss
Description: Carbonic anhydrases (CAs), also designated carbonate dehydratases or carbonate hydrolyases, form a large family of genes that encode zinc metalloenzymes of great physiologic importance. As catalysts of the reversible hydration of carbon dioxide, these enzymes participate in a variety of biologic processes, including respiration, acid-base balance, bone resorption and calcification as well as the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. Genes in the ?carbonic anhydrase family encode either active carbonic anhydrase isozymes or 揳catalytic?(devoid of CO2 hydration activity) carbonic anhydrase-related proteins. Human CA I (CA1) is encoded by the CA1 gene, which maps to a region on chromosome 8 that harbors a cluster of CA genes. CA I localizes to the cytoplasm and research indicates that a severe deficiency of CA I does not result in any obvious hematological or renal consequences.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8487R-CY3

Anti-FNDC3B Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-8487R-CY3)
Supplier: Bioss
Description: Adipogenesis, the process of transforming pre-adipocytes into mature fat cells, is of particular interest due to the role adipocytes play in obesity and type II diabetes. Adipocytes have been shown to affect a variety of functions, including hemostasis, angiogenesis and energy balance, by secreting hormones and bioactive peptides. The FNDC3B protein, also designated FAD104 (factor for adipocyte differentiation 104) or HCV NS5A-binding protein 37, is expressed during early adipogenesis. Belonging to the FNDC3 family of proteins, FNDC3B is a 1,204 amino acid protein that contains nine fibronectin type-III domains. FNDC3B-deficient mice die within one day of birth, suggesting that FNDC3B is crucial for postpartum survival. Mouse embryonic fibroblasts (MEFs) with loss of FNDC3B function displayed a reduction in stress fiber formation, indicating a role for FNDC3B in cell proliferation, adhesion, spreading and migration.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8487R-CY7

Anti-FNDC3B Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-8487R-CY7)
Supplier: Bioss
Description: Adipogenesis, the process of transforming pre-adipocytes into mature fat cells, is of particular interest due to the role adipocytes play in obesity and type II diabetes. Adipocytes have been shown to affect a variety of functions, including hemostasis, angiogenesis and energy balance, by secreting hormones and bioactive peptides. The FNDC3B protein, also designated FAD104 (factor for adipocyte differentiation 104) or HCV NS5A-binding protein 37, is expressed during early adipogenesis. Belonging to the FNDC3 family of proteins, FNDC3B is a 1,204 amino acid protein that contains nine fibronectin type-III domains. FNDC3B-deficient mice die within one day of birth, suggesting that FNDC3B is crucial for postpartum survival. Mouse embryonic fibroblasts (MEFs) with loss of FNDC3B function displayed a reduction in stress fiber formation, indicating a role for FNDC3B in cell proliferation, adhesion, spreading and migration.
UOM: 1 * 100 µl
Product Image-70-1243-U100

Anti-CD274 Rat Monoclonal Antibody [clone: 10F.9G2]

Catalog Number: (70-1243-U100)
Supplier: Tonbo Biosciences
Description: The 10F.9G2 antibody is specific for mouse CD274, more commonly known as PD-L1 or B7-H1, which acts as a ligand for the T cell co-regulatory receptor PD-1 (CD279). This interaction modulates T cell antigen receptor (TCR) signaling and therefore T cell activation. PD-L1 binding to PD-1 expressed on CD4- CD8- thymocytes participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-L1 may also bind PD-1 following the receptor’s inducible expression on activated, mature T cells, where it has been proposed to limit T cell activation. PD-L1 is one of a group of “B7” ligands whose interactions with the CD28 receptor family, also including CTLA-4 (CD152), provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.
UOM: 1 * 100 µG
Product Image-25-053-CI

Corning® Trypsin

Catalog Number: (25-053-CI)
Supplier: Corning
Description: 0,05% Trypsin/0,53 mM EDTA in HBSS (Hank’s Balanced Salt Solution) with sodium bicarbonate, without calcium and magnesium.
UOM: 1 * 6 items

MSDS Certificates


Product Image-DUPOTYCHA5TWH6X010

Chemical resistant overalls, Tyvek® 600 Plus, models CHA5a / CHA6

Supplier: DuPont
Description: These Tyvek® overalls are made from flash spun, high density polyethylene, providing an ideal balance of protection, durability and comfort. Tyvek® is permeable to both air and water vapour, yet repels water-based liquids and aerosols. It offers an excellent barrier against fine particles and fibres (down to 1 micron in size).

Product Image-SART14087-47-RDN

Nutrient Pad Sets, NKS e.motion

Supplier: Sartorius
Description: Nutrient pad sets for colony counting by the membrane filter method, specially designed for the Microsart e.motion dispenser. These nutrient pad consist of dehydrated culture media inserted into pre-sterilised Petri dishes. This alternative to agar media has a long storage life of 24 months at room temperature.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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