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Image Unavailable-BOSSBS-11172R

Anti-NAP1L2 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-11172R)
Supplier: Bioss
Description: Proper nucleosome assembly is critical for compacting DNA into chromatin. In human and mouse there are 5 protein-coding genes which comprise the nucleosome assembly protein (NAP) family. NAP1L1 (NAP1) and NAP1L4 (NAP2) are ubiquitously expressed family members which have been the most extensively studied. The remaining three family members, NAP1L2, NAP1L3 and NAP1L5 are neuron-specific nucleosome assembly proteins translated from intronless genes which are monoallelically expressed. NAP1L2 (nucleosome assembly protein 1-like 2), also known as BPX (brain specific protein, X-linked), is a 460 amino acid protein containing acidic domains which are thought to mediate histone interactions. NAP1L2 binds to chromatin and interacts with Histones H3 and H4. The function of NAP1L2 is not clearly defined although evidence suggests that NAP1L2 influences histone acetylation and therefore may play a significant role in regulating transcription in developing neurons.
UOM: 1 * 100 µl
Image Unavailable-APOSPC1100F-500MG

2-(1-Pyrrolidinyl)-5-(trifluoromethyl)aniline 97%

Catalog Number: (APOSPC1100F-500MG)
Supplier: Apollo Scientific
Description: 2-(1-Pyrrolidinyl)-5-(trifluoromethyl)aniline 97%
UOM: 1 * 500 mg
Image Unavailable-BOSSBS-13270R-A488

Anti-GALNT10 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-13270R-A488)
Supplier: Bioss
Description: The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosaminyl) to serine and threonine residues of various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-T10 (Polypeptide N-acetylgalactosaminyltransferase 10), also known as UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10, is a 603 amino acid single-pass type II membrane protein that prefers Muc5Ac and EA2 peptide substrates. The N-terminal domain is involved in substrate binding and manganese coordination, while the C-terminal domain is involved in UDP-Gal binding and catalytic reaction. GalNAc-T10 is widely expressed, with highest levels found in small intestine. There are four isoforms of GalNAc-T10 that are produced as a result of alternative splicing events.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8687R-CY7

Anti-p53 FL-393 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-8687R-CY7)
Supplier: Bioss
Description: p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8687R-HRP

Anti-p53 FL-393 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-8687R-HRP)
Supplier: Bioss
Description: p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8687R-CY5

Anti-p53 FL-393 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-8687R-CY5)
Supplier: Bioss
Description: p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
UOM: 1 * 100 µl
Image Unavailable-J63951.14

Ethyl violet

Supplier: Thermo Fisher Scientific
Description: Ethyl violet

MSDS Certificates

Image Unavailable-BOSSBS-13274R-A680

Anti-GALNT13/GalNAc-T13 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-13274R-A680)
Supplier: Bioss
Description: The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosamine) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-T13 (Polypeptide N-acetylgalactosaminyltransferase 13), also known as UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13, is a 556 amino acid protein that displays much stronger enzymatic activity than GalNAc-1 towards GalNAc transfer to mucin peptides such as Muc5a and Muc7. The N-terminal domain is involved in substrate binding and manganese coordination, while the C-terminal domain is involved in UDP-Gal binding and catalytic reaction. With specific expression in the central nervous system, GalNAc-T13 may be responsible for the synthesis of Tn antigen in neuronal cells, which is a universal carcinoma marker on malignant cells.
UOM: 1 * 100 µl
Image Unavailable-22866.22

Crystal violet 90+% ACS

Supplier: Thermo Fisher Scientific
Description: Crystal violet 90+% ACS

MSDS Certificates

Product Image-ACRO453930250

L-Phenylalanine 98.5-101.0%, meets analytical specification of USP

Supplier: Thermo Fisher Scientific
Description: L-Phenylalanine 98.5-101.0%, meets analytical specification of USP

MSDS

Image Unavailable-APOSBISN0195-1MG

BIX2188 Z-Isomer

Catalog Number: (APOSBISN0195-1MG)
Supplier: Apollo Scientific
Description: MAPK/ERK Signalling Pathway
UOM: 1 * 1 mg
Product Image-ACRO445250100

Diclofenac sodium salt 98%

Catalog Number: (ACRO445250100)
Supplier: Thermo Fisher Scientific
Description: Diclofenac sodium salt 98%
UOM: 1 * 10 g

MSDS


Image Unavailable-APOSOR307624-1G

DL-β-(4-Methoxyphenyl)alaninol

Catalog Number: (APOSOR307624-1G)
Supplier: Apollo Scientific
Description: DL-β-(4-Methoxyphenyl)alaninol
UOM: 1 * 1 g
Image Unavailable-BOSSBS-8687R-CY3

Anti-p53 FL-393 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-8687R-CY3)
Supplier: Bioss
Description: p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8687R-A647

Anti-p53 FL-393 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-8687R-A647)
Supplier: Bioss
Description: p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8687R-FITC

Anti-p53 FL-393 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-8687R-FITC)
Supplier: Bioss
Description: p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator, MDM2. MDM2 is an E3 ubiquitin ligase that is upregulated in the presence of active p53, where it poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active DNA-binding conformations and is differentially activated through posttranslational modifications, including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) of p53, amino acids 110-286, can compromise energetically-favorable association with cis elements and are implicated in several human cancers.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
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