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Catalog Number: (BOSSBS-0758R)
Supplier: Bioss
Description: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
UOM: 1 * 100 µl


Catalog Number: (TREV4253-096-03)
Supplier: TREVIGEN
Description: 96-Well Comet Slide 1 slide 1 * 1 items
UOM: 1 * 1 items

Market Source Item This is a MarketSource item. Additional charges may apply

Catalog Number: (SHAN172550)
Supplier: Epredia
Description: SLIDE BASKETS - 30 SLIDES 1 * 30 items
UOM: 1 * 30 items


Catalog Number: (TREV4800-30-41)
Supplier: TREVIGEN
Description: TACS Tissue Control Slides 5 slides 1 * 5 items
UOM: 1 * 5 items

Market Source Item This is a MarketSource item. Additional charges may apply

Catalog Number: (TREV3950-300-02)
Supplier: TREVIGEN
Description: FLARE Slides 100 slides 1 * 100 items
UOM: 1 * 100 items

Market Source Item This is a MarketSource item. Additional charges may apply

Catalog Number: (DIDAPOD066650)
Supplier: DIDALAB
Description: Slides, projection objects, set of 4 slides - 50x50mm. 1 * 1 items
UOM: 1 * 1 items


Catalog Number: (LEIH3802615)
Supplier: LEICA HISTOLOGY
Description: Cardboard slide folder for 20 slides 1 * 72 items
UOM: 1 * 72 items


Catalog Number: (HECH91270200028)
Supplier: GLASWARENFABRIK KARL HECHT
Description: SLIDE BOX FOR 50 MICROSCOPE SLIDES 1 * 30 items
UOM: 1 * 30 items


Catalog Number: (SHANB1781)
Supplier: Epredia
Description: Box, Slide, Plastic red for 25 slides 1 * 1 items
UOM: 1 * 1 items

New Product


Catalog Number: (TREV4252-200-01)
Supplier: TREVIGEN
Description: COMETASSAY(R) HT SLIDE 10 SLIDES 1 * 10 items
UOM: 1 * 10 items

Market Source Item This is a MarketSource item. Additional charges may apply

Catalog Number: (MSPPL12003-LG)
Supplier: MARKET SOURCE PART PROCESS
Description: LUNA Cell Counting Slides, 1000 Slides 1 * 1.000 items
UOM: 1 * 1.000 items

Market Source Item This is a MarketSource item. Additional charges may apply

Catalog Number: (TREV4253-960-03)
Supplier: TREVIGEN
Description: 96-Well Comet Slide 10 slides 1 * 10 items
UOM: 1 * 10 items

Market Source Item This is a MarketSource item. Additional charges may apply

Catalog Number: (TREV4253-10K-03)
Supplier: TREVIGEN
Description: 96-Well Comet Slide 100 slides 1 * 100 items
UOM: 1 * 100 items

Market Source Item This is a MarketSource item. Additional charges may apply

Catalog Number: (TREV4253-02K-03)
Supplier: TREVIGEN
Description: 96-Well Comet Slide 20 slides 1 * 20 items
UOM: 1 * 20 items

Market Source Item This is a MarketSource item. Additional charges may apply

Catalog Number: (SHAN147)
Supplier: Epredia
Description: HOLDER, SLIDE, 3 1 * 1 items
UOM: 1 * 1 items

New Product


Catalog Number: (HEWLG1600-24701)
Supplier: Agilent
Description: SLIDE SUPPORT 1 * 1 items
UOM: 1 * 1 items


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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