You Searched For: Quinoline-N-oxide+hydrate

Catalog Number: (BOSSBS-9474R-HRP)

Supplier: Bioss

Description: Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-9474R-CY3)

Supplier: Bioss

Description: Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-9474R-A750)

Supplier: Bioss

Description: Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localised to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localisation signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-15371R-HRP)

Supplier: Bioss

Description: Atypical chemokine receptor that controls chemokine levels and localisation via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalising receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalisation and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

UOM: 1 * 100 µl

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Catalog Number: (NEWPTLS182)

Supplier: NEW PIG

Description: The leak diverter made from PVC/polyester features drawstrings which cinch tightly around valves, fittings and other oddly shaped components to capture leaks at the source.

UOM: 1 * 1 items

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Catalog Number: (CAMP2179823)

Supplier: CAMPING GAZ

Description: Campingaz CV 470 Plus gas cartridge 4-Pack, valve cartridge with patented Easy Clic Plus Technology. It is suitable camping stoves, camping grills or lamps, 450 g butane/propane mix (80/20).

UOM: 1 * 1 items

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Catalog Number: (WITG8.445.003)

Supplier: witeg Labortechnik

Description: Water jet pumps made of brass and nickel-plated.

UOM: 1 * 1 items

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Catalog Number: (VARI12234005)

Supplier: VARIAN

Description: Waste tower repair kit, includes vacuum exit valve with exit tube, elbow and waste tower, For: Vac Elut™ SPS 24 vacuum manifold

UOM: 1 * 1 items

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Catalog Number: (903-0373)

Supplier: VWR Collection

Description: The ChromasterUltra Rs is the result of many years of research, development and experience, leading to the introduction of one of the most advanced, robust and easy to use UHPLC system available on the market today. Hitachi-High Technologies is a world leader in fluid control and optical analysis technology, as well as in high performance electronics. Hitachi has focused on combining the knowledge of these three key disciplines to give the world of chromatography one of the best instruments for today's demands. To arrange a demonstration with one of our experts, please email chromatography@eu.vwr.com.

UOM: 1 * 1 items

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Catalog Number: (BRAU4550587)

Supplier: B. Braun

Description: Mini Spike Plus withdrawal and injection spikes for multidose vials and multiple withdrawals.

UOM: 1 * 100 items

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Supplier: UPCHURCH SCIENTIFIC

Description: These PEEK sample loops are metal-free alternatives to stainless steel loops. PEEK loop ends are provided with clean, straight cuts for easy valve installation.

Supplier: HONEYWELL SAFETY

Description: Individually wrapped fold-flat respirators with the exclusive features of the Willson 5000 series: ultra-soft seal, new exhalation valve, latex, PVC, silicone-free materials.

Supplier: witeg Labortechnik

Description: Borosilicate glass.

Supplier: Agilent

Description: These fittings for Shimadzu HPLC systems provide leak-free connections and prevent the loss of peak shape and resolution.

Supplier: witeg Labortechnik

Description: Burettes, class AS, Schellbach blue line, conformity certified and made of clear borosilicate glass.

Catalog Number: (AZLOPWD003)

Supplier: SciLabware

Description: Water jet pump suitable for most laboratory water pressures with integrated non-return valve that increases safety and a detachable vacuum connection for 6 to 9 mm bore tubing.

UOM: 1 * 1 items

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