You Searched For: Ethyl+1H-indazole-3-carboxylate

Supplier: MP Biomedicals

Description: Used to reduce Con A binding to lymphocyte surface in culture.

Catalog Number: (468-4122)

Supplier: Bel-Art Products, a Part of SP

Description: This clear and durable PVC desiccator cabinet has sleek black ABS accents, a horizontal profile, and movable shelves for adjusting dry storage space configuration for moisture-sensitive materials.

UOM: 1 * 1 items

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Supplier: MP Biomedicals

Description: Synonyms: 7[S]-Chloro-7-deoxylincomycin; Cleocin Hydrochloride

Certificates

Catalog Number: (BOSSBS-12922R-A647)

Supplier: Bioss

Description: The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf’s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase).

UOM: 1 * 100 µl

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Supplier: Thermo Fisher Scientific

Description: Trehalose, dihydrate, is an inducer of autophagy, it protect cells against numerous environmental stresses. It is seldom used as a direct replacement for conventional sweeteners. Used as a cryoprotectant in a variety of cell freezing media.

MSDS Certificates

Catalog Number: (SAMPA324-120)

Supplier: Sampling Systems

Description: These ladles made from hygienic stainless steel are ideal for sampling liquid products. The ladles have a crevice free construction so that they can be easily cleaned between batches.

UOM: 1 * 1 items

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Catalog Number: (BOSSBS-2067R-CY3)

Supplier: Bioss

Description: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-2067R-FITC)

Supplier: Bioss

Description: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS.

UOM: 1 * 100 µl

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Supplier: Thermo Fisher Scientific

Description: IPTG (isopropyl-β-D-thiogalactopyranoside) 99% for biochemistry dioxane-free

MSDS

Catalog Number: (SCERSP885450-0025)

Supplier: DWK Life Sciences

Description: These borosilicate glass tissue grinders combine both conical and cylindrical surfaces to reduce tissue and also produces a uniform homogenate. Construction is strong enough to allow the pestle to be motor driven and also the grinding efficiency is greatly improved while using this tube.

UOM: 1 * 1 items

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Catalog Number: (471331000.)

Supplier: Thermo Fisher Scientific

Description: Paeoniflorin 95%

UOM: 1 * 100 mg

New Product Sale

Catalog Number: (PRSI56-664)

Supplier: ProSci Inc.

Description: SYTL1 may play a role in vesicle trafficking (By similarity). It binds phosphatidylinositol 3,4,5-triphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).

UOM: 1 * 400 µl

New Product Sale

Catalog Number: (48712-5)

Supplier: Merck Millipore (Oncogene)

Description: (2-Nitrophenyl)-β-D-galactopyranoside (ONPG), Millipore®

UOM: 1 * 5 g

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Catalog Number: (MOLE12691995-25G)

Supplier: Molekula

Description: 2-Deoxy-D(-)-ribose

UOM: 1 * 25 g

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 This is a MarketSource item. Additional charges may apply

Supplier: Thermo Fisher Scientific

Description: X-Gal (5-bromo-4-chloro-3-indolyl-ß-D-galactopyranoside) ≥98%

MSDS

Catalog Number: (BOSSBS-12922R-A350)

Supplier: Bioss

Description: The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf’s activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase).

UOM: 1 * 100 µl

Sale