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Anti-CD178 (Fas ligand) Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: NOK-1]

Supplier: Tonbo Biosciences
Description: The NOK-1 antibody reacts with human CD178 (Fas ligand) in both membrane bound and soluble forms. Fas ligand is a 40 kDa transmembrane glycoprotein, a member of the TNF family, and is expressed by activated T and NK cells, neutrophils, and monocytes. Interactions between CD178 (Fas ligand) and CD95 (Fas) induce a program of apoptosis and play a key role in immune regulation and homeostasis. The extracellular domain of human CD178 can be cleaved from the surface by matrix metalloproteinases (MMPs) resulting in a 26 kDa soluble protein.

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Anti-CD45 Mouse Monoclonal Antibody (PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®) [clone: 2D1]

Supplier: Tonbo Biosciences
Description: The 2D1 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, and CD45RO.

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Anti-CD2 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: RPA-2.10]

Supplier: Tonbo Biosciences
Description: The RPA-2.10 antibody reacts with human CD2, an approximately 50 kDa glycoprotein, and a member of the Ig superfamily. CD2, also known as LFA-2, is a receptor for CD58 in the human and is expressed on the cell surface of 80-90% of human peripheral blood lymphocytes, a subset of NK cells, and all mature T cells. CD2 mediates lymphocyte adhesion and is involved in T cell activation.

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Anti-CD4 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: SK3]

Supplier: Tonbo Biosciences
Description: The SK3 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The SK3 antibody is widely used as a phenotypic marker for human CD4 expression, and has been reported to be cross-reactive with Rhesus and Cynomolgus CD4. This antibody does not block binding of alternative clone RPA-T4, suggesting that they recognize different epitopes.

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Anti-CD2 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: RPA-2.10]

Supplier: Tonbo Biosciences
Description: The RPA-2.10 antibody reacts with human CD2, an approximately 50 kDa glycoprotein, and a member of the Ig superfamily. CD2, also known as LFA-2, is a receptor for CD58 in the human and is expressed on the cell surface of 80-90% of human peripheral blood lymphocytes, a subset of NK cells, and all mature T cells. CD2 mediates lymphocyte adhesion and is involved in T cell activation.

Product Image-80-0088-T025

Anti-CD8a Mouse Monoclonal Antibody (redFluor™ 710) [clone: RPA-T8]

Supplier: Tonbo Biosciences
Description: The RPA-T8 antibody is specific for the 32 to 34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

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Anti-CD5 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: UCHT2]

Supplier: Tonbo Biosciences
Description: The UCHT2 antibody is specific for human CD5, a 67 kD transmembrane glycoprotein, that is expressed on most thymocytes, mature T cells, and a subset of B cells. CD5 is involved in modulating antigen receptor signaling in both T and B cells and binds to CD72, expressed on B cells.

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Anti-IgG Goat Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (72-8120-M001)
Supplier: Tonbo Biosciences
Description: Goat anti-Human IgG Fc - Affinity Pure, HRP Conjugate
UOM: 1 * 1 mg
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Anti-CD16 / CD32 Rat Monoclonal Antibody (PE (Phycoerythrin)-Cyanine7) [clone: 2.4G2]

Supplier: Tonbo Biosciences
Description: The 2.4G2 antibody is specific for a common epitope found in the extracellular regions of mouse Fc-receptors Fc-gamma II (CD32) and Fc-gamma III (CD16). These receptors are expressed by B cells, monocytes, macrophages, NK cells, dendritic cells, and neutrophils.

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Anti-IgG Goat Polyclonal Antibody (AP (Alkaline Phosphatase))

Catalog Number: (22-8042-M001)
Supplier: Tonbo Biosciences
Description: Goat anti-Mouse IgG (H&L) - Affinity Pure, Alkaline Phosphatase Conjugate
UOM: 1 * 1 mg
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Anti-KLRB1 Mouse Monoclonal Antibody (PE-Cyanine7) [clone: PK136]

Supplier: Tonbo Biosciences
Description: The PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1 (Ehlers et al. 2012. Endocrinology. 10: 1247). The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524).

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Anti-SELL Rat Monoclonal Antibody (PerCP-Cyanine5.5) [clone: MEL-14]

Supplier: Tonbo Biosciences
Description: The MEL-14 antibody is specific for mouse CD62L, also known as L-Selectin, a cell adhesion molecule which facilitates lymphocyte "rolling" on activated vascular endothelium and homing to high endothelial venules (HEV) as immune cells transmigrate from blood into peripheral tissues. L-Selectin is a member of a family of Selectin molecules which act together with the integrin family of adhesion molecules to mediate leukocyte-endothelial interactions. L-Selectin is characteristically expressed by neutrophils, and is also found on B cells, monocytes, granulocytes, and at varying levels on naive, effector and memory T cells. It is rapidly shed upon cell activation, releasing into the circulation a soluble form whose biological role is of particular interest in cancer biology research. The MEL-14 antibody may be used as a phenotypic marker for CD62L expression on a variety of immune cell types. Please note that CD62L (L-Selectin) itself is also referred to as MEL-14 in the literature.

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Anti-IgG Sheep Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (72-8078-M001)
Supplier: Tonbo Biosciences
Description: Sheep anti-Rabbit IgG (H&L) - Affinity Pure, HRP Conjugate
UOM: 1 * 1 mg
Image Unavailable-72-8068-M001

Anti-IgG Goat Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (72-8068-M001)
Supplier: Tonbo Biosciences
Description: Goat anti-Rabbit IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/ bovine, goat, human, mouse or rat IgG or serum
UOM: 1 * 1 mg
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Anti-IgG Goat Polyclonal Antibody (PE (Phycoerythrin))

Catalog Number: (50-8036-U100)
Supplier: Tonbo Biosciences
Description: Goat anti-Rabbit IgG, secondary antibody, conjugated toSureLight® R-Phycoerythrin
UOM: 1 * 100 µG
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Anti-IgG Donkey Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (72-8085-M001)
Supplier: Tonbo Biosciences
Description: Donkey anti-Sheep IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/human, mouse, or rabbit IgG
UOM: 1 * 1 mg
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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