You Searched For: 3-Bromo-5-chlorobenzyl+alcohol


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Catalog Number: (BOSSBS-0192R-A555)
Supplier: Bioss
Description: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.
UOM: 1 * 100 µl


Catalog Number: (USBIP4256-34K)
Supplier: US Biological
Description: Anti-Plasminogen Activator Inhibitor Type I Mouse Monoclonal Antibody [clone: 9B9]
UOM: 1 * 100 µl


Catalog Number: (USBIP4256-31Y2)
Supplier: US Biological
Description: Anti-Plasminogen Activator Inhibitor Type 1 Mouse Monoclonal Antibody (Biotin) [clone: 9L786]
UOM: 1 * 150 µG


Catalog Number: (BOSSBS-6203R-A750)
Supplier: Bioss
Description: p53 activated protein 2.
UOM: 1 * 100 µl


Catalog Number: (USBIP4256-31Z1)
Supplier: US Biological
Description: Anti-Plasminogen Activator Inhibitor Type 1, Non-Inhibitory Mouse Monoclonal Antibody
UOM: 1 * 1 mg


Catalog Number: (USBIS1014-19R5)
Supplier: US Biological
Description: Anti-Slo2.2 Sodium Activated Potassium Channel Mouse Monoclonal Antibody [clone: 10F770]
UOM: 1 * 100 µG


Catalog Number: (USBIE3015-04)
Supplier: US Biological
Description: Anti-Endothelial Monocyte Activating Polypeptide II Mouse Monoclonal Antibody [clone: 6A542]
UOM: 1 * 100 µG


Catalog Number: (USBI041028-APC)
Supplier: US Biological
Description: Anti-Rho GTPase-activating protein 36 Rabbit Polyclonal Antibody (APC (Allophycocyanin))
UOM: 1 * 200 µl


Catalog Number: (USBI041028-PE)
Supplier: US Biological
Description: Anti-Rho GTPase-activating protein 36 Rabbit Polyclonal Antibody (PE (Phycoerythrin))
UOM: 1 * 200 µl


Catalog Number: (BOSSBS-2739R-A680)
Supplier: Bioss
Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
UOM: 1 * 100 µl


Catalog Number: (USBIA1475-01U)
Supplier: US Biological
Description: Anti-AMP Activated Protein Kinase alpha1/2 Mouse Monoclonal Antibody [clone: 9E22]
UOM: 1 * 100 µG


Supplier: SIGMA ALDRICH MICROSCOPY
Description: Bromobimane is also known as monobromobimane. It is also a known probe for thiols and is a fluorescent reagent activated upon a photolysis reaction.

Supplier: Thermo Fisher Scientific
Description: Sodium percarbonate 13 - 14% (active oxygen)
Catalog Number: (ENZOBMLAK5310001)
Supplier: ENZO LIFE SCIENCES
Description: The HDAC3/NCOR1 Fluorescent Activity Assay/Drug Discovery Kit is a complete assay system designed to measure the lysyl deacetylase activity of the recombinant human HDAC3 included in the kit. The kit is ideal for chemical library screening for candidate inhibitors or activators or kinetic assay of the enzyme under varying conditions.
UOM: 1 * 1 KIT


Catalog Number: (BOSSBS-0984R-CY7)
Supplier: Bioss
Description: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
UOM: 1 * 100 µl


Catalog Number: (ENZOBMLSE5440050)
Supplier: ENZO LIFE SCIENCES
Description: Highly active
UOM: 1 * 50 µG


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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