You Searched For: 3,4-Dimethoxy-L-phenylalanine


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Supplier: Biotium
Description: Recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.

Catalog Number: (MOLEM21789468)
Supplier: Molekula
Description: 3-(3,4-Dihydroxyphenyl)-L-alanine
UOM: 1 * 25 g

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Catalog Number: (PROOICRS0334)
Supplier: LGC Standards PROMOCHEM
Description: 3-(3,4-Dihydroxyphenyl)-L-alanine
UOM: 1 * 100 mg


Catalog Number: (MOLE36580840-100G)
Supplier: Molekula
Description: 3,4-Dimethoxybenzoic acid
UOM: 1 * 100 g

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Catalog Number: (PROOMM0262.00)
Supplier: LGC Standards PROMOCHEM
Description: 3-(3,4-Dihydroxyphenyl)-L-alanine
UOM: 1 * 500 mg


Catalog Number: (PROOMM0319.01)
Supplier: LGC Standards PROMOCHEM
Description: 3,4-Dimethoxybenzoic acid
UOM: 1 * 100 mg


Catalog Number: (PROOBP213)
Supplier: LGC Standards PROMOCHEM
Description: 3-(3,4-Dihydroxyphenyl)-L-alanine
UOM: 1 * 100 mg


Catalog Number: (BSENR-148-50)
Supplier: Biosensis
Description: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. FUNCTION: Plays an important role in the physiology of adrenergic neurons. CATALYTIC ACTIVITY: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin. COFACTOR: Fe(2+) ion. ENZYME REGULATION: Phosphorylation leads to an increase in the catalytic activity. PATHWAY: Catecholamine biosynthesis; first step. SUBUNIT: Homotetramer. PTM: In vitro, phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation, which results in enzyme opening and activation. SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency as low dopamine levels are a consistent neurochemical abnormality.
UOM: 1 * 50 µG


Catalog Number: (BSENM-1616-100)
Supplier: Biosensis
Description: Tyrosine hydroxylase is an excellent marker for dopaminergic and noradrenergic neurons. Tyrosine hydroxylase (a.k.a. tyrosine 3-monooxygenase) is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). L-DOPA is a precursor for dopamine, which, in turn, is a precursor for the important neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). Tyrosine hydroxylase catalyzes the rate limiting step in this synthesis of catecholamines. In humans, tyrosine hydroxylase is encoded by the TH gene, and the enzyme is present in the central nervous system (CNS), peripheral symphatic neurons and the adrenal medulla. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing. Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases (AAAHs). http://en.wikipedia.org/wiki/Tyrosine_hydroxylase
UOM: 1 * 100 µl


Catalog Number: (MOLEM43971872)
Supplier: Molekula
Description: Veratraldehyde
UOM: 1 * 500 g

Market Source Item This is a MarketSource item. Additional charges may apply

Catalog Number: (MOLE25751471-100G)
Supplier: Molekula
Description: 3,4-Dimethoxybenzyl alcohol
UOM: 1 * 100 g

Market Source Item This is a MarketSource item. Additional charges may apply

Catalog Number: (MOLE24539542-100G)
Supplier: Molekula
Description: 4-Methylveratrole
UOM: 1 * 100 g

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Catalog Number: (MOLEM11112649)
Supplier: Molekula
Description: 3,5-Dimethoxybenzaldehyde
UOM: 1 * 25 g

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Supplier: Roth Carl
Description: Veratraldehyde

Supplier: MP Biomedicals
Description: L-3,4-Dihydroxyphenylalanine (L-DOPA), an anti-Parkinsonian agent, is the natural isomer of the immediate precursor to dopamine. L-DOPA is the product of the hydroxylation of L-tyrosine by tyrosine hydroxylase in brain and in adrenal medulla.

Catalog Number: (PRSI34-177)
Supplier: ProSci Inc.
Description: Recognises a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This mAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyses several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this mAb shows tyrosinase in melanotic as well as amelanotic variants. This mAb is a useful marker for melanocytes and melanomas.
UOM: 1 * 100 µG

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