You Searched For: 4\'-Chlorobiphenyl-4-carboxylic+acid

Catalog Number: (BOSSBS-5935R-CY3)

Supplier: Bioss

Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.

UOM: 1 * 100 µl

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Catalog Number: (ENZOBMLP3030005)

Supplier: ENZO LIFE SCIENCES

Description: Proteinase substrate

UOM: 1 * 5 mg

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Catalog Number: (ENZOALX480019M010)

Supplier: ENZO LIFE SCIENCES

Description: DNA alkyltransferase substrate and inhibitor

UOM: 1 * 10 mg

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Catalog Number: (BOSSBS-5104R-CY3)

Supplier: Bioss

Description: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-3263R-CY5)

Supplier: Bioss

Description: MARCKS, (Myristoylated Alanine-Rich C Kinase Substrate), is a member of a family of calmodulin binding proteins and is a major substrate for phosphorylation by protein kinase C (PKC). The phosphorylation of Ser152/156 can be used as a measure of PKC activation. Phosphorylation of Ser152/156 modulates the binding of MARCKS to calmodulin.

UOM: 1 * 100 µl

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Catalog Number: (ENZOBMLP8020005)

Supplier: ENZO LIFE SCIENCES

Description: Proteasome substrate

UOM: 1 * 5 mg

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Catalog Number: (BOSSBS-5935R-A750)

Supplier: Bioss

Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-5104R-A647)

Supplier: Bioss

Description: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.

UOM: 1 * 100 µl

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Supplier: G-Biosciences

Description: A ready to use modified BCIP (5-Bromo-4-Chloro-3’-Indolyphosphate p-Toluidine salt) and NBT (Nitro-Blue Tetrazolium Chloride) substrate that generates a black-purple insoluble precipitate in the presence of alkaline phosphatase.

Catalog Number: (ENZOBMLP1440001)

Supplier: ENZO LIFE SCIENCES

Description: S6 kinase substrate

UOM: 1 * 1 mg

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Supplier: Apollo Scientific

Description: Substrate for N-Acetyl-b-D-glucosaminidase

Supplier: Apollo Scientific

Description: Optical brightner. Highly effective in polymer substrates such as engineering plastics (polyesters, polycarbonate, polyamides and acrylics, thermoplastic polyurethane, polyvinylchloride, styrene homo- and copolymers, polyolefins), adhesives and other organic substrates.

Catalog Number: (BOSSBS-10228R-A680)

Supplier: Bioss

Description: The protein encoded by this gene can hydrolyse substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumour suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene.

UOM: 1 * 100 µl

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Catalog Number: (ENZOALX155023M001)

Supplier: ENZO LIFE SCIENCES

Description: Specific PKC substrate

UOM: 1 * 1 mg

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Catalog Number: (ENZOBMLAK5180001)

Supplier: ENZO LIFE SCIENCES

Description: A Fluor-de-Lys® fluorescent assay system. The HDAC8 Fluorescent Activity Assay/Drug Discovery Kit is a complete assay system designed to measure the lysyl deacetylase activity of the recombinant human HDAC8 included in the kit. The kit is ideal for chemical library screening for candidate inhibitors or activators or kinetic assay of the enzyme under varying conditions. The Fluor de Lys® HDAC8 assay is based on the Fluor de Lys® Substrate and Fluor de Lys® Developer combination. The assay procedure has two steps. First, the Fluor de Lys® Substrate, which comprises an acetylated lysine side chain, is incubated with HDAC6. Deacetylation of the substrate sensitizes the substrate so that, in the second step, treatment with the Fluor de Lys®Developer produces a fluorophore.

UOM: 1 * 1 KIT

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Catalog Number: (BOSSBS-1135R-A680)

Supplier: Bioss

Description: c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labelling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr --> Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.

UOM: 1 * 100 µl

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