You Searched For: (4-Pyridylthio)acetic+acid

Description: Bismuth ≥99.999% (metals basis), rods, Ø 12.7 mm (0.5 in)

Catalog Number: 35854.22

UOM: 1 * 100 g

Supplier: Thermo Fisher Scientific

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Description: Bismuth ≥99.99% (metals basis), rods, Ø 11 mm (0.43 in)

Catalog Number: 41534.14

UOM: 1 * 25 g

Supplier: Thermo Fisher Scientific

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Description: Bismuth ≥99.5% (metals basis), powder -100 mesh

Catalog Number: 10110.A3

UOM: 1 * 2 kg

Supplier: Thermo Fisher Scientific

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Description: Bismuth ≥99.999% (metals basis), powder -200 mesh

Catalog Number: 10766.22

UOM: 1 * 100 g

Supplier: Thermo Fisher Scientific

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Description: Bismuth ≥99.999% (metals basis), foil, Thickness: 1.0 mm (0.04 in)

Catalog Number: 41636.FF

UOM: 1 * 1 items

Supplier: Thermo Fisher Scientific

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Description: Bismuth ≥99.999% (metals basis), foil, Thickness: 2.0 mm (0.08 in)

Catalog Number: 41637.FF

UOM: 1 * 1 items

Supplier: Thermo Fisher Scientific

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Description: Bismuth ≥99.998% (metals basis), needles 1-5 cm, Length: 1-5 cm (0.4-2 in)

Catalog Number: 10109.36

UOM: 1 * 500 g

Supplier: Thermo Fisher Scientific

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Description: Bismuth ≥99.9% (metals basis), rods, Ø 12.7 mm (0.5 in)

Catalog Number: 00915.A1

UOM: 1 * 1 kg

Supplier: Thermo Fisher Scientific

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Description: Bismuth ≥99.99% (metals basis), pieces ≤ 10 cm (3.9 in)

Catalog Number: 12208.A1

UOM: 1 * 1 kg

Supplier: Thermo Fisher Scientific

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Description: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1.

Catalog Number: BOSSBS-5531R

UOM: 1 * 100 µl

Supplier: Bioss

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Description: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1.

Catalog Number: BOSSBS-3494R-CY5.5

UOM: 1 * 100 µl

Supplier: Bioss

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Description: Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1.

Catalog Number: BOSSBS-3494R-CY3

UOM: 1 * 100 µl

Supplier: Bioss

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Description: Bismuth Standard, 10000 mg/L, Specpure®, Bismuth, Matrix: 5% HNO₃, Application: ICP standards

Catalog Number: 14388.AD

UOM: 1 * 50 mL

Supplier: Thermo Fisher Scientific

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Description: Bismuth Standard, 1000 mg/L, Specpure®, Bismuth, Matrix: 5% HNO₃, Application: ICP standards

Catalog Number: 13822.AP

UOM: 1 * 500 mL

Supplier: Thermo Fisher Scientific

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Description: Bismuth ≥99.9% (metals basis), ingot/button, Ø ∼36 mm (1.4 in), Thickness: 8 mm (0.3 in)

Catalog Number: 45102.KF

UOM: 1 * 1 items

Supplier: Thermo Fisher Scientific

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Description: Bismuth Standard, 5000 µg/g, Specpure®, Bismuth, Matrix: Mineral oil, Application: Oil based standards

Catalog Number: 43865.18

UOM: 1 * 50 g

Supplier: Thermo Fisher Scientific

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