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Description: MYEF2 is the transcriptional repressor of the myelin basic protein gene (MBP). MYEF2 binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA.

Catalog Number: PRSI31-256

UOM: 1 * 50 µG

Supplier: ProSci Inc.

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Description: TAF5L functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Catalog Number: PRSI31-261

UOM: 1 * 50 µG

Supplier: ProSci Inc.

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Description: Anti-FOXO4 Goat Polyclonal Antibody

Catalog Number: PRSI45-623

UOM: 1 * 100 µG

Supplier: ProSci Inc.

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Description: Anti-FOXN1 Goat Polyclonal Antibody

Catalog Number: PRSI45-619

UOM: 1 * 100 µG

Supplier: ProSci Inc.

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Description: Matrix metalloproteinase-12（MMP12） is a secreted protein.It contains 4 hemopexin repeats and belongs to the peptidase M10A family. MMP12 may be involved in tissue injury and remodeling and have significant elastolytic activity. It can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

Catalog Number: PRSI91-577

UOM: 1 * 50 µG

Supplier: ProSci Inc.

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Description: Mouse CCL24 is a secreted protein, which is a member of the CC chemokine subfamily. Mouse Ccl24 cDNA encodes a 119 amino acid residue precursor protein, shares approximately 58% amino acid sequence identity with human Ccl24. It is predominantly expressed in the jejunum and spleen and also be induced in the lung by allergen challengeand IL4. Mouse ccl24 has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Ccl24 is chemotactic for resting T-lymphocytes, eosinophils and can bind to CCR3. LPS and IL4 also differentially regulate the expression of Ccl24 in monocytes and macrophages.

Catalog Number: PRSI91-581

UOM: 1 * 50 µG

Supplier: ProSci Inc.

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Description: Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, and lymphoid organs. Cxcl12 activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. It also binds to atypical chemokine receptor ACKR3 which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Cxcl12 has several critical functions during embryonic development such as B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Cxcl12 plays an important role in acting as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. It stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. It also plays a protective role after myocardial infarction, induces down-regulation and internalization of ACKR3 expressed in various cells and stimulates the proliferation of bone marrow-derived b progenitor cells in the presence of IL-7 as well as growth of the stromal cell-dependent B-cell clone DW34 cells.

Catalog Number: PRSI91-583

UOM: 1 * 50 µG

Supplier: ProSci Inc.

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Description: Anti-IL1R2 Rabbit Polyclonal Antibody

Catalog Number: PRSI49-434

UOM: 1 * 50 µG

Supplier: ProSci Inc.

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Description: DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. DTX2 probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context and mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. It also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Catalog Number: PRSI29-852

UOM: 1 * 50 µG

Supplier: ProSci Inc.

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Description: Chloride intracellular channel protein 3 (CLIC3) is encoded by the CLIC3 gene. CLIC3 is a single-pass membrane protein which belongs to the chloride channel CLIC family. It contains one GST C-terminal domain and one GST N-terminal domain. Chloride intracellular channel protein 3 high expressed in the placental, lung and heart, low expressed in skeletal muscle, kidney and pancreas. Chloride intracellular channel protein 3 can insert into membranes and forms chloride ion channels, may participate in cellular growth control.

Catalog Number: PRSI92-188

UOM: 1 * 50 µG

Supplier: ProSci Inc.

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Description: Anti-RXRG Goat Polyclonal Antibody

Catalog Number: PRSI46-324

UOM: 1 * 100 µG

Supplier: ProSci Inc.

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Description: Anti-TRIM69 Goat Polyclonal Antibody

Catalog Number: PRSI46-311

UOM: 1 * 100 µG

Supplier: ProSci Inc.

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Description: Anti-EXOSC9 Goat Polyclonal Antibody

Catalog Number: PRSI46-967

UOM: 1 * 100 µG

Supplier: ProSci Inc.

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Description: Anti-TRIM21 Goat Polyclonal Antibody

Catalog Number: PRSI46-314

UOM: 1 * 100 µG

Supplier: ProSci Inc.

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Description: Anti-TFAP2D Goat Polyclonal Antibody

Catalog Number: PRSI46-957

UOM: 1 * 100 µG

Supplier: ProSci Inc.

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Description: Anti-PLEKHB1 Goat Polyclonal Antibody

Catalog Number: PRSI46-974

UOM: 1 * 100 µG

Supplier: ProSci Inc.

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