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Anti-CD8A Mouse Monoclonal Antibody (CF568) [clone: C8/468]

Supplier: Biotium
Description: CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 α/β) or as a homodimer (CD8 α/α). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4 /CD8-. Anaplastic large cell lymphoma is usually CD4 and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Image Unavailable-BNC880386-500

Anti-CD8A Rabbit Polyclonal Antibody (CF488A) [clone: Rabbit PAb]

Supplier: Biotium
Description: CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 α/β) or as a homodimer (CD8 α/α). A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4 /CD8-. Anaplastic large cell lymphoma is usually CD4 and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Image Unavailable-BNUM0386-50

Anti-CD8A Rabbit Polyclonal Antibody (Purified, BSA-free) [clone: Rabbit PAb]

Catalog Number: (BNUM0386-50)
Supplier: Biotium
Description: CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 β chain (CD8 α/β) or as a homodimer (CD8 α/α). A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4 /CD8-. Anaplastic large cell lymphoma is usually CD4 and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
UOM: 1 * 50 µl
Product Image-MLDVR8341

Cell viability assay kits, EarlyTox™ live/dead assay kits

Supplier: Molecular Devices
Description: EarlyTox™ Cell Viability Assay Kits are a family of fluorescence-based reagents for the assessment of cell viability, cell proliferation, and various apoptosis events using mammalian cells. Optimised for use with microplate readers, these assay kits employ a no-wash, homogeneous assay protocol that enables characterisation of a full concentration-response profile of test compounds.

Product Image-NANOCS-050

Chamber slides, C-Slide

Catalog Number: (NANOCS-050)
Supplier: NANOENTEK
Description: Cell counting chamber slides for use with automated cell counter (Countess and Countess II).
UOM: 1 * 50 items

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Image Unavailable-BOSSBS-6848R-CY5.5

Anti-FSCN1 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (BOSSBS-6848R-CY5.5)
Supplier: Bioss
Description: Fascin is a highly conserved actin-bundling protein. Fascin, encoded by the human homolog for sn (hsn) gene, has been localized to microspikes and stress fibers of cultured cells where it is thought to be involved in the formation of microfilament bundles. It is expressed predominantly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative. However, Reed Sternberg cells in Hodgkin’s lymphoma are positive for fascin staining. Epstein-Barr virus may induce expression of fascin in B cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0938R-A647

Anti-KLRK1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-0938R-A647)
Supplier: Bioss
Description: Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins.
UOM: 1 * 100 µl
Image Unavailable-USBIS7975-13C

Anti-Stromal Cell Derived Factor 1alpha Goat Polyclonal Antibody (Biotin)

Catalog Number: (USBIS7975-13C)
Supplier: US Biological
Description: Anti-Stromal Cell Derived Factor 1alpha Goat Polyclonal Antibody (Biotin)
UOM: 1 * 50 µG
Image Unavailable-BNC470811-100

Anti-ZAP70 Mouse Monoclonal Antibody (CF647) [clone: 2F3.2]

Supplier: Biotium
Description: ZAP70 is a 70 kDa protein tyrosine kinase found in T-cells and natural killer cells. Control of this protein translation is via the IgVH gene.In Western blotting of whole cell lysates of normal peripheral blood mononuclear cells, the antibody labels a band corresponding to ZAP70. In Western blotting of whole cell lysates of CD19-positive purified leukemia cells from patients with Ig-unmutated and Ig-mutated CLL, the antibody labels a band corresponding to ZAP70 in the Ig-unmutated CLL samples, whereas no band is observed in the Ig-mutated CLL samples. In Western blotting of cell lysates of Jurkat cells (T-lymphoblastic cell line), the antibody labels a band of 70 kDa protein. In Western blotting of cell lysates of A431 cells (carcinoma cell line), no band is observed. ZAP70 protein is expressed in leukemic cells of approximately 25% of chronic lymphocytic leukemia (CLL) cases as well. Anti-ZAP70 expression is an excellent surrogate marker for the distinction between the Ig-mutated (anti-ZAP70 negative) and Ig-unmutated (anti-ZAP70 positive) CLL subtypes and can identify patient groups with divergent clinical courses. The anti-ZAP70 positive Ig-unmutated CLL cases have been shown to have a poorer prognosis.

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Accessories for VWR® Hitachi UH4150 UV-Vis/NIR Spectrophotometers

Supplier: VWR Collection
Description: Accessory for UV/Visible spectrophotometers, Cell holder, rectangular, for 10 mm cell, For: UH4150

Image Unavailable-BOSSBS-2583R-CY5

Anti-ICOS Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-2583R-CY5)
Supplier: Bioss
Description: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
UOM: 1 * 100 µl
Product Image-50-5961-U100

Anti-TCRB Armenian Hamster Monoclonal Antibody (PE) [clone: H57-597]

Supplier: Tonbo Biosciences
Description: The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.</p><p>The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.

Image Unavailable-USBI138117

Anti-Mast Cell Rabbit Polyclonal Antibody

Catalog Number: (USBI138117)
Supplier: US Biological
Description: Anti-Mast Cell Rabbit Polyclonal Antibody
UOM: 1 * 5 mL
Image Unavailable-USBIM2414-01G

Anti-Mast Cell Protease 1 Sheep Polyclonal Antibody

Catalog Number: (USBIM2414-01G)
Supplier: US Biological
Description: Anti-Mast Cell Protease 1 Sheep Polyclonal Antibody
UOM: 1 * 100 µG
Image Unavailable-BNC470914-100

Anti-NGFR Mouse Monoclonal Antibody (CF647) [clone: NGFR5 NTR/912]

Supplier: Biotium
Description: This antibody recognizes a glycoprotein of 75 kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR is a reliable marker for desmoplastic and neurotropic melanomas. NGFR is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.

Image Unavailable-734-0132

Cellware, collagen Type I, Corning® BioCoat™

Catalog Number: (734-0132)
Supplier: Corning
Description: These Corning® BioCoat™ Collagen I Cellware consists of a family of collagen-coated cultureware products including inserts, micro and multiwell plates, flasks, coverslips, and culture slides.
UOM: 1 * 24 items

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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The original product is no longer available. The replacement shown is available.
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