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Anti-NKX2-2 Mouse Monoclonal Antibody (CF405S) [clone: NX2/294]

Supplier: Biotium
Description: Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.

Product Image-P5C8-100AF

Avantor® Partisil C8, HPLC Columns

Supplier: Avantor
Description: Avantor® Partisil® was one of the first commercially available irregular silicas with a large surface area giving it a high loading capacity.

Image Unavailable-BOSSBS-13387R-A647

Anti-GOX Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-13387R-A647)
Supplier: Bioss
Description: Glucose Oxidase is a dimeric enzyme that binds to β-D-glucose and aids in its oxidation into D-glucono-1,5-lactone which then hydrolyzes to gluconic acid. Flavin adenine dinucleotide (FAD) is a cofactor to Glucose Oxidase that acts as the initial electron acceptor and is required for this oxidation to occur. Glucose Oxidase is a natural preservative found in honey, where it reduces atmospheric oxygen into hydrogen peroxide which acts as an antibacterial barrier. Glucose Oxidase is also commonly used in biosensors in which it conveys levels of glucose by keeping track of the number of electrons passed through the enzyme. In this application, Glucose Oxidase is connected to an electrode and the resulting charge is measured.
UOM: 1 * 100 µl
Image Unavailable-BNC470447-100

Anti-TMEM16A Mouse Monoclonal Antibody (CF647) [clone: DG1/447]

Supplier: Biotium
Description: Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.

Image Unavailable-22140-5KG

Celite® 545, filter aid ≥99% ≤125.30 μm (71% (acc. Cilas)), treated with sodium carbonate, flux calcined, Fluka™

Catalog Number: (22140-5KG)
Supplier: Honeywell Chemicals
Description: Celite® 545, filter aid ≥99% ≤125.30 μm (71% (acc. Cilas)), treated with sodium carbonate, flux calcined, Fluka™
UOM: 1 * 5 kg

MSDS


Image Unavailable-BOSSBS-4819R-A750

Anti-CD45 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-4819R-A750)
Supplier: Bioss
Description: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4224R-A488

Anti-UGT1A9 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-4224R-A488)
Supplier: Bioss
Description: UGT1A9 is a UDP glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N termini and identical C termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. UGT1A9 is active on phenols.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6280R-CY3

Anti-FUT8 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-6280R-CY3)
Supplier: Bioss
Description: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3252R-CY5

Anti-ALOX5 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-3252R-CY5)
Supplier: Bioss
Description: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0526R-CY5.5

Anti-ALOX5 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (BOSSBS-0526R-CY5.5)
Supplier: Bioss
Description: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
UOM: 1 * 100 µl
Image Unavailable-APOSBIC0115-25G

Cephalothin sodium salt

Supplier: Apollo Scientific
Description: First generation cephalosporin antibiotic. Disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It is effective against gram-positive and gram-negative bacteria.

Image Unavailable-CAYM82100-100

DEA NONOate ≥98%, crystalline solid

Supplier: Cayman Chemical
Description: DEA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 2 minutes and 16 minutes at 37 °C and 22 to 25 °C, pH 7.4, respectively, to liberate 1.5 moles of NO per mole of parent compound.

Image Unavailable-BOSSBS-15086R-A555

Anti-C1r Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-15086R-A555)
Supplier: Bioss
Description: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
UOM: 1 * 100 µl
Image Unavailable-BNC040093-500

Anti-PGF Mouse Monoclonal Antibody (CF405S) [clone: PLGF93]

Supplier: Biotium
Description: The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF) and Placenta Growth Factor (PLGF). Placenta growth factor (PLGF) is a secreted protein primarily produced by placental trophoblasts but also expressed in other endothelial cells and tumors. There are three isoforms, PLGF-1, PLGF-2, and PLGF-3. PLGF-2 is expressed up until week 8 in the placenta; the placental tissues continuously express PLGF-1 and PLGF-3 but only PLGF-1 is found in colon and mammary carcinomas. PLGF acts to stimulate angiogenesis, endothelial growth and migration. PLGF is a powerful promoter of tumor growth and is upregulated in some cancers, and PLGF is thought to aid in atherosclerotic lesions and neovascular growth surrounding the lesion. Also, PLGF appears to aid aldosterone mediated atherosclerosis. Serum levels of PLGF in some cases are used as a potential biomarker for disease or genetic defect. Recent research indicates that PLGF levels are lower in mothers with Down syndrome fetuses. Evidence has suggested VEGF to be an obligatory component in PLGF signaling. While VEGF homodimers and VEGF/PLGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PLGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PLGF. VEGF and PLGF share a common receptor, Flt-1, and may also activate Flk-1/KDR.

Image Unavailable-BNUM0093-50

Anti-PGF Mouse Monoclonal Antibody (Purified, BSA-free) [clone: PLGF93]

Catalog Number: (BNUM0093-50)
Supplier: Biotium
Description: The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described. These include Fibroblast Growth Factor (FGF), Platelet Derived Growth Factor (PDGF), Vascular Endothelial Growth Factor (VEGF) and Placenta Growth Factor (PLGF). Placenta growth factor (PLGF) is a secreted protein primarily produced by placental trophoblasts but also expressed in other endothelial cells and tumors. There are three isoforms, PLGF-1, PLGF-2, and PLGF-3. PLGF-2 is expressed up until week 8 in the placenta; the placental tissues continuously express PLGF-1 and PLGF-3 but only PLGF-1 is found in colon and mammary carcinomas. PLGF acts to stimulate angiogenesis, endothelial growth and migration. PLGF is a powerful promoter of tumor growth and is upregulated in some cancers, and PLGF is thought to aid in atherosclerotic lesions and neovascular growth surrounding the lesion. Also, PLGF appears to aid aldosterone mediated atherosclerosis. Serum levels of PLGF in some cases are used as a potential biomarker for disease or genetic defect. Recent research indicates that PLGF levels are lower in mothers with Down syndrome fetuses. Evidence has suggested VEGF to be an obligatory component in PLGF signaling. While VEGF homodimers and VEGF/PLGF heterodimers function as potent mediators of mitogenic and chemotactic responses in endothelial cells, PLGF homodimers are effectual only at extremely high concentrations. Indeed, many of the physiological effects attributed to VEGF may actually be a result of VEGF/PLGF. VEGF and PLGF share a common receptor, Flt-1, and may also activate Flk-1/KDR.
UOM: 1 * 50 µl
Product Image-BOSSBS-6613R

Anti-BCAT1 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-6613R)
Supplier: Bioss
Description: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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