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Catalog Number: (ABCAAB242440-100)
Supplier: Abcam
Description: Anti-Endothelin A Receptor/ET-A Rabbit Monoclonal Antibody [clone: UMB-8-37-1]
UOM: 1 * 100 µG


Catalog Number: (422361V)
Supplier: VWR Chemicals
Description: A protease-free grade albumin for RIA and ELISA applications, produced by a heat-shock process in caprylic acid.
UOM: 1 * 100 g

Catalog Number: (M167-10MG)
Supplier: VWR Chemicals
Description: A competitive and reversible serine protease inhibitor of chymotrypsin, trypsin, kallikrein and plasmin. Not an inhibitor of Factor Xa and thrombin.
UOM: 1 * 10 mg

Catalog Number: (BOSSBS-3325R-CY5.5)
Supplier: Bioss
Description: PAR4 is a member of a unique family of GPCRs, the proteinase-activated receptors (PARs), that are activated by proteolytic cleavage of the N-terminal domain of the receptor to reveal a tethered ligand. The PAR family consists of 4 receptors; PAR1 and PAR3 are activated by thrombin, and PAR2 and PAR4 are activated by several serine proteases (Macfarlane et al., 2001). PAR4 is expressed along with PAR1 on human platelets, and each plays an important role in thrombin-induced platelet aggregation (Holinstat et al., 2006). However, platelets from mice express PAR4 but not PAR1, and platelets from mice lacking PAR4 fail to aggregate in response to thrombin (Sambrano et al., 2001). Mice lacking PAR4 are protected from mesenteric arteriole thrombosis, indicating that PAR4 is a potential target for treatment of thrombosis in humans.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-3325R-CY7)
Supplier: Bioss
Description: PAR4 is a member of a unique family of GPCRs, the proteinase-activated receptors (PARs), that are activated by proteolytic cleavage of the N-terminal domain of the receptor to reveal a tethered ligand. The PAR family consists of 4 receptors; PAR1 and PAR3 are activated by thrombin, and PAR2 and PAR4 are activated by several serine proteases (Macfarlane et al., 2001). PAR4 is expressed along with PAR1 on human platelets, and each plays an important role in thrombin-induced platelet aggregation (Holinstat et al., 2006). However, platelets from mice express PAR4 but not PAR1, and platelets from mice lacking PAR4 fail to aggregate in response to thrombin (Sambrano et al., 2001). Mice lacking PAR4 are protected from mesenteric arteriole thrombosis, indicating that PAR4 is a potential target for treatment of thrombosis in humans.
UOM: 1 * 100 µl


Supplier: SIGMA ALDRICH MICROSCOPY
Description: Reichardt′s dye belongs to the class of azo merocyanine dyes. Reichardt′s dye, also known as ET(30) or pyridinium N-phenoxyde betaine dye is a highly solvatochromic betaine dye useful for determining solvent polarity effects. It plays an important role as a probe of solvent polarity in biological systems and on surfaces. Reichardt’s dye, a solvatochromic betaine dye has been used for the determination of solvent polarity.

Catalog Number: (1.13934.5000)
Supplier: Merck
Description: Spectromelt® C 20 grinding and tabletting aid, for X-ray analysis, Supelco®
UOM: 1 * 5 kg

Catalog Number: (BOSSBS-13114R-A488)
Supplier: Bioss
Description: ETV3L is a transcriptional regulator, which belongs to the ETS family and contains 1 ETS DNA-binding domain.
UOM: 1 * 100 µl


Catalog Number: (20771.236)
Supplier: VWR Chemicals
Description: VWR®, Chicken native albumin (from egg)
UOM: 1 * 250 g

Catalog Number: (ABCAAB219358-50)
Supplier: Abcam
Description: Anti-Endothelin A Receptor/ET-A Rabbit Polyclonal Antibody
UOM: 1 * 50 µG


Catalog Number: (ENZOADI905790100)
Supplier: ENZO LIFE SCIENCES
Description: Endothelins are vasoactive peptides that exist in three forms (ET-1, ET-2, and ET-3), and function in the maintenance of vascular tone via two identified seven transmembrane-spanning domain-containing G protein-coupled receptors (GPCR), endothelin A (ETA) and endothelin B (ETB). The human ETA receptor is primarily expressed in vascular smooth muscle cells, including those of the heart (also in myocytes), lung, and brain, and its stimulation generally results in vasoconstriction. Activation of ETA receptors can be stimulated by binding of ET-1 and ET-2, but not ET-3. triggering the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells. Human ETB receptors are primarily expressed in endothelial cells lining the vessel walls of the lungs, heart, and brain, and in contrast to ETA receptors, stimulation generally results in transient vasodilation. Activation of ETB receptors can be stimulated by binding of all three endothelins, triggering the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells. Both ETA and ETB receptors signal primarily via coupling to Gq/11 alpha subunits, although Gi/o and Gs coupling are also established mechanisms of endothelin signaling, resulting in stimulation of phospholipases C, A2, and D.
UOM: 1 * 100 µG


Supplier: ENZO LIFE SCIENCES
Description: Isolated from mouse submaxillary glands by a modification of the procedure described by T. Darling, et al.; Cell Culture Meth. Mol. Cell Biol. 4, 79 (1984).

Catalog Number: (ENZOALX200606M001)
Supplier: ENZO LIFE SCIENCES
Description: Purified from human brain by method of Määttä <i>et al..</i>
UOM: 1 * 1 mg


Catalog Number: (ENZOALX521006C010)
Supplier: ENZO LIFE SCIENCES
Description: Isolated from mouse submaxillary glands by a modification of the procedure described by T. Darling, et al.; Cell Culture Meth. Mol. Cell Biol. 4, 79 (1984).
UOM: 1 * 10 µG


Catalog Number: (BOSSBS-3325R-A555)
Supplier: Bioss
Description: PAR4 is a member of a unique family of GPCRs, the proteinase-activated receptors (PARs), that are activated by proteolytic cleavage of the N-terminal domain of the receptor to reveal a tethered ligand. The PAR family consists of 4 receptors; PAR1 and PAR3 are activated by thrombin, and PAR2 and PAR4 are activated by several serine proteases (Macfarlane et al., 2001). PAR4 is expressed along with PAR1 on human platelets, and each plays an important role in thrombin-induced platelet aggregation (Holinstat et al., 2006). However, platelets from mice express PAR4 but not PAR1, and platelets from mice lacking PAR4 fail to aggregate in response to thrombin (Sambrano et al., 2001). Mice lacking PAR4 are protected from mesenteric arteriole thrombosis, indicating that PAR4 is a potential target for treatment of thrombosis in humans.
UOM: 1 * 100 µl


Catalog Number: (1.01031.0500)
Supplier: Merck
Description: Aluminium ammonium sulphate dodecahydrate, EMSURE® for analysis, Supelco®
UOM: 1 * 500 g

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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