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Description: AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
Catalog Number: BOSSBS-0115R-A488
UOM: 1 * 100 µl
Supplier: Bioss


Description: Human Rad1 is a component of a heterotrimeric PCNA like complex that also contains the Rad9 and Hus1 proteins. This complex is believed to be involved in cellular responses to DNA damage, possibly by associating with Rad17 and several components of the PCNA-loading heteropentamer, replication factor C. Human Rad1 exhibits significant homology to Rad1 from S. pombe, and its expression in yeast rad1 mutants has been shown to partially restore radiation resistance and G2 checkpoint activity. It has also been shown to possess exonuclease activity.
Catalog Number: BOSSBS-0278R-A647
UOM: 1 * 100 µl
Supplier: Bioss


Description: AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
Catalog Number: BOSSBS-0876R-FITC
UOM: 1 * 100 µl
Supplier: Bioss


Description: Anti-UVRAG Rabbit Polyclonal Antibody
Catalog Number: USBIU8975
UOM: 1 * 100 µG
Supplier: US Biological


Description: No more eye strain - front shield magnifies scale 16 percent for easier readings.
Catalog Number: MFLX32005-12
UOM: 1 * 1 items
Supplier: Avantor Fluid Handling


Description: These safety shields are made from transparent acrylic glass of 8 mm thick.
Catalog Number: ROTH2967.1
UOM: 1 * 1 items
Supplier: Roth Carl


Description: Human Rad1 is a component of a heterotrimeric PCNA like complex that also contains the Rad9 and Hus1 proteins. This complex is believed to be involved in cellular responses to DNA damage, possibly by associating with Rad17 and several components of the PCNA-loading heteropentamer, replication factor C. Human Rad1 exhibits significant homology to Rad1 from S. pombe, and its expression in yeast rad1 mutants has been shown to partially restore radiation resistance and G2 checkpoint activity. It has also been shown to possess exonuclease activity.
Catalog Number: BOSSBS-0278R-CY5.5
UOM: 1 * 100 µl
Supplier: Bioss


Description: Human Rad1 is a component of a heterotrimeric PCNA like complex that also contains the Rad9 and Hus1 proteins. This complex is believed to be involved in cellular responses to DNA damage, possibly by associating with Rad17 and several components of the PCNA-loading heteropentamer, replication factor C. Human Rad1 exhibits significant homology to Rad1 from S. pombe, and its expression in yeast rad1 mutants has been shown to partially restore radiation resistance and G2 checkpoint activity. It has also been shown to possess exonuclease activity.
Catalog Number: BOSSBS-0278R-CY7
UOM: 1 * 100 µl
Supplier: Bioss


Description: Human Rad1 is a component of a heterotrimeric PCNA like complex that also contains the Rad9 and Hus1 proteins. This complex is believed to be involved in cellular responses to DNA damage, possibly by associating with Rad17 and several components of the PCNA-loading heteropentamer, replication factor C. Human Rad1 exhibits significant homology to Rad1 from S. pombe, and its expression in yeast rad1 mutants has been shown to partially restore radiation resistance and G2 checkpoint activity. It has also been shown to possess exonuclease activity.
Catalog Number: BOSSBS-0278R-CY3
UOM: 1 * 100 µl
Supplier: Bioss


Description: These lightweight cover glasses (OTG) are designed to fit over most prescription spectacles with minimal interference. Available in three lens options. The green lens offers protection against infrared radiation arising from certain gas welding, gas cutting and brazing applications (IR shade 5).
Catalog Number: MMMA2805
UOM: 1 * 1 items
Supplier: 3M


Description: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.
Catalog Number: BOSSBS-12533R-CY5
UOM: 1 * 100 µl
Supplier: Bioss


Description: Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0,5 to 1,5 micrometers and numbering 100 to 300 per cell, enable bacteria to colonise the epithelium of specific host organs. FanC is the main component of the K99 fimbriae.
Catalog Number: BOSSBS-4920R-A680
UOM: 1 * 100 µl
Supplier: Bioss


Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Catalog Number: BOSSBS-8571R-A555
UOM: 1 * 100 µl
Supplier: Bioss


Description: Everest columns have unique selectivity and sensitivity, which are the result of bonding technology that improves C18 surface coverage and deactivates residual silanols. Previously, the 300 Å C18 chemistries had carbon coverage in the 2,8 to 3,6 µmol/m² range. Everest C18 coverage is in excess of 4 µmol/m² and approximates the theoretical limit based on surface area. The increased shielding of the base silica increases column lifetime and reduces the amount of TFA required to shield the silica.
Catalog Number: 238EV5.07515
UOM: 1 * 1 items
Supplier: Avantor


Description: AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalisation. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
Catalog Number: BOSSBS-10133R-A680
UOM: 1 * 100 µl
Supplier: Bioss


Description: Human Rad1 is a component of a heterotrimeric PCNA like complex that also contains the Rad9 and Hus1 proteins. This complex is believed to be involved in cellular responses to DNA damage, possibly by associating with Rad17 and several components of the PCNA-loading heteropentamer, replication factor C. Human Rad1 exhibits significant homology to Rad1 from S. pombe, and its expression in yeast rad1 mutants has been shown to partially restore radiation resistance and G2 checkpoint activity. It has also been shown to possess exonuclease activity.
Catalog Number: BOSSBS-0278R-A488
UOM: 1 * 100 µl
Supplier: Bioss


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