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Catalog Number: (BOSSBS-0836R-CY3)
Supplier: Bioss
Description: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
UOM: 1 * 100 µl


Catalog Number: (HICH88925)
Supplier: Avantor
Description: Avantor® Alltima HPLC columns are high quality phases designed for general purpose applications.
UOM: 1 * 1 items


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Supplier: Liebherr
Description: These are heavy duty MediLine models with forced air cooling. The controller features door and temperature alarms which can be customised to suit the end user. Controller can be locked. The refrigerant used is hydrocarbon. Units have 83 to 60 mm insulation and 2 castors with brakes.

Catalog Number: (HT110332-1L)
Supplier: SIGMA ALDRICH MICROSCOPY
Description: General purpose cytoplasmic counterstain. Used with hematoxylin and eosin staining.
UOM: 1 * 1 L

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Supplier: VWR Collection
Description: This disposable coat is made of non woven, laminated, SPP fabric.
Supplier: Liebherr
Description: High-volume freezers with forced air cooling. White steel exterior and stainless-steel interior. The intuitive user interfaces provide useful extended multi-functionality, e.g. a maintenance timer, and the LED interior lighting ensures good visibility of the contents of these large appliances. Advanced connectivity options to suit varying requirements for simplified data storage, temperature control and alarm signals.

New Product

Supplier: KIMBERLY CLARK
Description: These single use wipes made from single ply AIRFLEX* material are ideal for multipurpose cleaning and medium duty wiping tasks such as polishing glass, smooth surfaces and cleaning tools.

Supplier: Avantor
Description: General purpose column for solvent impurities, PCBs, hydrocarbons, essential oils, semivolatiles, triglycerides, pesticides, poly-waxes, etc.

Catalog Number: (SCAA473242)
Supplier: Essity
Description: The 1-ply multipurpose Tork Reflex™ Wiping Paper is ideal for wiping tasks and hand wiping, due to its strength and high absorption. This paper can be used in the Tork Reflex™ single-sheet centerfeed dispenser, which fits your team’s workflow, cuts down consumption, and minimises the risk of crosscontamination.
UOM: 1 * 6 items

New Product


Supplier: Brady
Description: These safety signs are for the purposes of accident prevention, fire protection, health hazard information and emergency evacuation.

Catalog Number: (113-9205)
Supplier: HUBEI ORIENT INTL TRADING
Description: Disposable pleated mob caps made from soft non woven PP.
UOM: 1 * 1.000 items


Catalog Number: (HT1103128-4L)
Supplier: SIGMA ALDRICH MICROSCOPY
Description: General purpose cytoplasmic counterstain. Used with hematoxylin and eosin staining.
UOM: 1 * 4 L


Supplier: KIMBERLY CLARK
Description: The WypAll® X80 Range has been specially designed for heavy-duty, rough surface wiping, where strength and bulk are key requirements. WypAll® X80 cloths do not tear and maintaining consistency in quality and size.

Supplier: Avantor
Description: Avantor® Alltima HPLC columns are high quality phases designed for general purpose applications.

Supplier: Avantor
Description: Avantor® Alltima HP columns features for general purpose normal-phase applications.

Catalog Number: (KIMB38714)
Supplier: KIMBERLY CLARK
Description: These surface preparation wipes are ideal for applications in transportation and industrial manufacturing.
UOM: 1 * 360 items


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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