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Supplier: Avantor
Description: Avantor® Alltima HPLC columns are high quality phases designed for general purpose applications.

Supplier: Avantor Fluid Handling
Description: Ideal for general-purpose applications.

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Supplier: Avantor
Description: Avantor® Alltima HPLC columns are high quality phases designed for general purpose applications.

Supplier: Avantor
Description: Avantor® Alltima HPLC columns are high quality phases designed for general purpose applications.

Catalog Number: (BOSSBS-0836R-CY5.5)
Supplier: Bioss
Description: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-0836R-A750)
Supplier: Bioss
Description: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
UOM: 1 * 100 µl


Supplier: Avantor
Description: Avantor® Alltima HPLC columns are high quality phases designed for general purpose applications.

Supplier: Avantor
Description: Avantor® Alltima HP columns features for general purpose normal-phase applications.

Supplier: VWR Collection
Description: These thermometers meet all requirements for physical dimensions and accuracy.

Supplier: VWR Collection
Description: Disposable mob caps made of PP. Ideal for use in non critical environments.

Supplier: Brady
Description: General-purpose vinyl labels feature a specially formulated topcoat for improved durability and colour.

New Product

Supplier: HUBEI ORIENT INTL TRADING
Description: These disposable overalls are made from non woven PP. Ideal for non critical applications in industrial, clinical or food processing environments.

Catalog Number: (HT1103128-4L)
Supplier: SIGMA ALDRICH MICROSCOPY
Description: General purpose cytoplasmic counterstain. Used with hematoxylin and eosin staining.
UOM: 1 * 4 L


Supplier: Kautex
Description: HDPE. Square. Natural colour. With moulded hand-grip.

Supplier: Ludwig Schneider GmbH & CO. KG
Description: These stem type thermometers with red filing are suitable for general purpose applications.

Catalog Number: (471-0483)
Supplier: Liebherr
Description: These spark-free laboratory freezers feature static cooling with an electronic controller system ensuring high temperature consistency and uniform temperature distribution. They are designed especially for storing explosive and highly flammable substances but are also suitable for non spark-free applications for the storage of temperature-sensitive and high value products.
UOM: 1 * 1 items


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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