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Product Image-KAUT311-83981

Container, wide mouth, square, threaded

Supplier: Kautex
Description: HDPE. Square. Natural colour. With moulded hand-grip.

Image Unavailable-BOSSBS-0836R-A350

Anti-MLH1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-0836R-A350)
Supplier: Bioss
Description: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
UOM: 1 * 100 µl

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Image Unavailable-BOSSBS-0836R-A488

Anti-MLH1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-0836R-A488)
Supplier: Bioss
Description: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0836R-CY5

Anti-MLH1 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-0836R-CY5)
Supplier: Bioss
Description: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
UOM: 1 * 100 µl
Product Image-BOSSBS-0836R

Anti-MLH1 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-0836R)
Supplier: Bioss
Description: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis.
UOM: 1 * 100 µl
Product Image-115-2527

Service and retail wiping paper, centrefeed roll, WypAll® Reach™

Catalog Number: (115-2527)
Supplier: KIMBERLY CLARK
Description: WypAll® L10 centrefeed roll is blue roll designed for light-duty hygiene wiping and designed for use in retail and service environments. Compatible with the portable WypAll® Reach™ dispenser (115-2528) which ensures rolls remain enclosed to help prevent against transmission of food-borne bacteria.
UOM: 1 * 6 Roll
Product Image-115-2051

Wipe rolls, WYPALL* L40

Catalog Number: (115-2051)
Supplier: KIMBERLY CLARK
Description: These single ply wipes are made from AIRFLEX* material, a specialised fabric with a perfect balance of softness and strength, that is also thick and absorbent. Ideal for industrial tasks such as cleaning, process line wiping, soaking up large spills.
UOM: 1 * 1 Roll
Product Image-PPSA2660006

Cleaning cloths, Clino® Ultra CR

Supplier: PFENNIG REINIGUNGSTECHNIK
Description: Reusable cloth for use on all non structured, smooth surfaces.

Product Image-620-0818

VWR®, Dry Block/Incubator Liquid-in-Glass Thermometers

Supplier: VWR Collection
Description: Contains red organic liquid against white back glass, except for 620-0891 which has yellow back glass.

Image Unavailable-HT110332-1L

Eosin Y solution, alcoholic , with Phloxine, Sigma-Aldrich®

Catalog Number: (HT110332-1L)
Supplier: SIGMA ALDRICH MICROSCOPY
Description: General purpose cytoplasmic counterstain. Used with hematoxylin and eosin staining.
UOM: 1 * 1 L

MSDS


Image Unavailable-819-0144

ESD cellulose tape, plastic core, Wescorp

Supplier: DESCO
Description: Wescorp ESD cellulose tape, plastic core are used for general purpose ESD tape applications.

Product Image-734-2981

VWR® Cell Chambers

Supplier: VWR Collection
Description: VWR® cell chambers, made from medical grade, general purpose polystyrene (GPPS) and with vented cap, are ideal for large-scale cell culture.

Environmentally Preferable

Product Image-BRDY176628

Brady® Vinyl Labels for BradyJet™ J7300 Colour Label Printer

Supplier: Brady
Description: General-purpose vinyl labels feature a specially formulated topcoat for improved durability and colour.

New Product

Product Image-BRDY361626

Labels for BBP33 printers, type B-8423

Supplier: Brady
Description: These polyester labels are used for product and general purpose identification, bin and shelf identification, barcoding and asset tracking.

Product Image-HICH88925

Avantor® Alltima, HPLC Columns, AQ

Catalog Number: (HICH88925)
Supplier: Avantor
Description: Avantor® Alltima HPLC columns are high quality phases designed for general purpose applications.
UOM: 1 * 1 items
Product Image-LIEBSFPVG8401

Performance and Perfection Laboratory Freezers with Stainless Steel Inner Liner, SFPvh and SFPvg

Supplier: Liebherr
Description: High-volume freezers with forced air cooling. White steel exterior and stainless-steel interior. The intuitive user interfaces provide useful extended multi-functionality, e.g. a maintenance timer, and the LED interior lighting ensures good visibility of the contents of these large appliances. Advanced connectivity options to suit varying requirements for simplified data storage, temperature control and alarm signals.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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