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Catalog Number: (BOSSBS-5398R-A350)
Supplier: Bioss
Description: IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.
UOM: 1 * 100 µl


Catalog Number: (ENZOBMLEW98050100)
Supplier: ENZO LIFE SCIENCES
Description: This solution contains pre-coupled Mg-ATP for immediate use as an energy source for a range of ATP-dependent reactions (e.g. ubiquitin thioester conjugation, proteasomal degradation, SUMO conjugation).
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-1980R-CY3)
Supplier: Bioss
Description: Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-1980R-CY5.5)
Supplier: Bioss
Description: Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-9584R-CY7)
Supplier: Bioss
Description: Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-å and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3∫ appears to be activated by both while Stat3å is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-9584R-A350)
Supplier: Bioss
Description: Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-å and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3∫ appears to be activated by both while Stat3å is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-10234R-CY7)
Supplier: Bioss
Description: Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity.
UOM: 1 * 100 µl


Supplier: ENZO LIFE SCIENCES
Description: PLA2 activator

Catalog Number: (BOSSBS-9452R-CY7)
Supplier: Bioss
Description: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
UOM: 1 * 100 µl


Catalog Number: (USBIP4256-32M-10)
Supplier: US Biological
Description: Anti-Plasminogen Activator Inhibitor Type 1 Goat Polyclonal Antibody
UOM: 1 * 10 µG


Catalog Number: (USBIP4256-34T)
Supplier: US Biological
Description: Anti-Plasminogen Activator Inhibitor Type 1 Rabbit Polyclonal Antibody
UOM: 1 * 1 mg


Catalog Number: (BOSSBS-2449R-CY3)
Supplier: Bioss
Description: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
UOM: 1 * 100 µl


Catalog Number: (BOSSBS-2485R-CY7)
Supplier: Bioss
Description: JAK2 (Janus Activating Kinase 2) is a tyrosine kinase of the non-receptor type, that associates with the intracellular domains of cytokine receptors; JAK2 is the predominant JAK kinase activated in response to several growth factors and cytokines such as IL-3, GM-CSF and erythropoietin; it has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon. Ligand binding to a variety of cell surface receptors (e.g., cytokine, growth factor, GPCRs) leads to an association of those receptors with JAK proteins, which are then activated via phosphorylation on tyrosines 1007 and 1008 in the kinase activation loop. Activated JAK proteins phosphorylate and activate STAT (signal transducers and activators of transcription) proteins, which then dimerize and translocate to the nucleus. Once in the nucleus, STAT proteins bind to DNA and modify the transcription of various genes.
UOM: 1 * 100 µl


Catalog Number: (ABCAAB32354-1ML)
Supplier: Abcam
Description: Anti-Phospholipase A2 activator protein (PLAP) Rabbit Monoclonal Antibody [clone: Y102]
UOM: 1 * 1 mL

New Product


Catalog Number: (ABCAAB181225-1ML)
Supplier: Abcam
Description: Anti-E1 Ubiquitin Activating Enzyme 1/UBA1 Rabbit Monoclonal Antibody [clone: EPR14204(B)]
UOM: 1 * 1 mL

New Product


Catalog Number: (ENZOENZ60002C005)
Supplier: ENZO LIFE SCIENCES
Description: Modulator of embryogenesis and known effector of tissue development and morphogenesis
UOM: 1 * 5 µG


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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