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Image Unavailable-BOSSBS-0076R-A680

Anti-beta Amyloid 1-42 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-0076R-A680)
Supplier: Bioss
Description: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalisation of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalysed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses.
UOM: 1 * 100 µl
Product Image-ACRO223120050

Nickel (II) oxide, black 76% Ni

Supplier: Thermo Fisher Scientific
Description: Nickel (II) oxide, black 76% Ni

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Image Unavailable-44663.09

Copper(II) oxide, powder_nano

Supplier: Thermo Fisher Scientific
Description: Copper(II) oxide, powder_nano

MSDS Certificates

Image Unavailable-12359.18

Nickel (II) oxide 99 Metals basis

Supplier: Thermo Fisher Scientific
Description: Nickel (II) oxide 99 Metals basis

MSDS Certificates

Image Unavailable-14240.A1

Lead(II) oxide 99,99 Metals basis

Supplier: Thermo Fisher Scientific
Description: Lead(II) oxide 99,99 Metals basis

MSDS Certificates

Image Unavailable-42940.22

Titanium(II) oxide 99,9 Metals basis, pellets

Supplier: Thermo Fisher Scientific
Description: Titanium(II) oxide 99,9 Metals basis, pellets

MSDS Certificates

Image Unavailable-BOSSBS-2527R-CY5

Anti-CD163 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-2527R-CY5)
Supplier: Bioss
Description: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
UOM: 1 * 100 µl
Product Image-ACRO199995000

Mercury (II) oxide, red 99%

Supplier: Thermo Fisher Scientific
Description: Mercury (II) oxide, red 99%

MSDS

Image Unavailable-42939.36

Titanium(II) oxide 99,9 Metals basis

Supplier: Thermo Fisher Scientific
Description: Titanium(II) oxide 99,9 Metals basis

MSDS Certificates

Product Image-8824-05

Zinc oxide 99.0-100.5% (excluding ignited substances) USP, Macron Fine Chemicals™

Supplier: MACRON AVANTOR BRAND
Description: Zinc oxide 99.0-100.5% (excluding ignited substances) USP, Macron Fine Chemicals™

MSDS Certificates

Image Unavailable-BOSSBS-2527R-A488

Anti-CD163 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-2527R-A488)
Supplier: Bioss
Description: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
UOM: 1 * 100 µl
Image Unavailable-11041.09

Palladium(II) oxide monohydrate 99.9_Pd_73 Metals basis

Supplier: Thermo Fisher Scientific
Description: Palladium(II) oxide monohydrate 99.9_Pd_73 Metals basis

MSDS Certificates

Image Unavailable-A17889.0E

Tin(II) oxide 99

Supplier: Thermo Fisher Scientific
Description: Tin(II) oxide 99

MSDS

Image Unavailable-10700.14

Copper(II) oxide ≥99.995% (metals basis), Puratronic®

Supplier: Thermo Fisher Scientific
Description: Copper(II) oxide ≥99.995% (metals basis), Puratronic®

MSDS Certificates

Image Unavailable-89430.18

Silicon(II) oxide 99,8 Metals basis, Optical Grade Optical Grade

Supplier: Thermo Fisher Scientific
Description: Silicon(II) oxide 99,8 Metals basis, Optical Grade Optical Grade

MSDS Certificates

Image Unavailable-1.10004.0001

Test strips for iron, MQuant®, Supelco®

Catalog Number: (1.10004.0001)
Supplier: Merck
Description: MQuant® (MQ) test strips can be considered as a mobile laboratory on a few square millimeters of plastic strip. As a screening method they provide the user with a rapid overview of the situation, which helps in making the choice of what, and perhaps if, further analysis is required, thereby leading to potentially substantial savings in time and analytical resources. The strip is a biologically-degradable polyester foil and the low reagent content, in the reaction zones, assists problem-free waste disposal.
UOM: 1 * 100 Tests

MSDS Certificates


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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