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Image Unavailable-BOSSBS-1373R-HRP

Anti-Lipocalin 2 Rabbit Polyclonal Antibody (HRP (Horseradish PE (Phycoerythrin)rOxidase))

Catalog Number: (BOSSBS-1373R-HRP)
Supplier: Bioss
Description: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds Iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes Iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of Iron and subsequent increase of intracellular Iron concentration. In contrast, association of the Iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, Iron chelation and Iron transfer to the extracellular medium, thereby reducing intracellular Iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: Iron-loaded form increases intracellular Iron concentration without promoting apoptosis, while Iron-free form decreases intracellular Iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating Iron, leading to limit bacterial growth.
UOM: 1 * 100 µl
Image Unavailable-USBII8615-75E

Anti-Iron Responsive Element Binding Protein 2 Goat Polyclonal Antibody

Catalog Number: (USBII8615-75E)
Supplier: US Biological
Description: Anti-Iron Responsive Element Binding Protein 2 Goat Polyclonal Antibody
UOM: 1 * 100 µG
Image Unavailable-PRSI91-967

Human Recombinant NGAL (from Cells)

Catalog Number: (PRSI91-967)
Supplier: ProSci Inc.
Description: LCN2 is iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. LCN2 binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. LCN2 is involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. LCN2 is involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
UOM: 1 * 0,05 mg

New Product


Image Unavailable-MFLX07600-30

Cast iron float and thermostatic steam traps (parallel configuration)

Catalog Number: (MFLX07600-30)
Supplier: Avantor Fluid Handling
Description: Keep steam space free of condensate to provide maximum system efficiency.
UOM: 1 * 1 items
Image Unavailable-BOSSBS-1373R-CY3

Anti-Lipocalin 2 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-1373R-CY3)
Supplier: Bioss
Description: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds Iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes Iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of Iron and subsequent increase of intracellular Iron concentration. In contrast, association of the Iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, Iron chelation and Iron transfer to the extracellular medium, thereby reducing intracellular Iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: Iron-loaded form increases intracellular Iron concentration without promoting apoptosis, while Iron-free form decreases intracellular Iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating Iron, leading to limit bacterial growth.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1373R-CY5

Anti-Lipocalin 2 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-1373R-CY5)
Supplier: Bioss
Description: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds Iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes Iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of Iron and subsequent increase of intracellular Iron concentration. In contrast, association of the Iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, Iron chelation and Iron transfer to the extracellular medium, thereby reducing intracellular Iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: Iron-loaded form increases intracellular Iron concentration without promoting apoptosis, while Iron-free form decreases intracellular Iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating Iron, leading to limit bacterial growth.
UOM: 1 * 100 µl
Product Image-HYCLSH30072.02

Calf serum, iron supplemented, US origin, HyClone™

Supplier: HyClone products (Cytiva)
Description: HyClone™ iron-supplemented bovine calf serum contains additional iron to boost serum transferrin levels to physiological levels.

MSDS

Image Unavailable-ABCAAB146273-1

Hematin (from porcine blood) iron-containing porphyrin

Catalog Number: (ABCAAB146273-1)
Supplier: Abcam
Description: Iron-containing porphyrin, used in a study to test in vitro activities of Rx-01 oxazolidinones against hospital and community pathogens.
UOM: 1 * 1 g
Image Unavailable-BOSSBS-5907R-FITC

Anti-FTH1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-5907R-FITC)
Supplier: Bioss
Description: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5907R-A350

Anti-FTH1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-5907R-A350)
Supplier: Bioss
Description: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13395R-HRP

Anti-GLRX5 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-13395R-HRP)
Supplier: Bioss
Description: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4906R-HRP

Anti-SLC40A1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-4906R-HRP)
Supplier: Bioss
Description: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8296R-CY5

Anti-TMPRSS6 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-8296R-CY5)
Supplier: Bioss
Description: Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter.Involvement in disease:Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA); also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0444R-A750

Anti-Slc22A17 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-0444R-A750)
Supplier: Bioss
Description: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalisation of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalisation of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0444R-HRP

Anti-SLC22A17 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-0444R-HRP)
Supplier: Bioss
Description: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0444R-A350

Anti-SLC22A17 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-0444R-A350)
Supplier: Bioss
Description: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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