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Image Unavailable-BOSSBS-12335R-A555

Anti-HFE Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Catalog Number: (BOSSBS-12335R-A555)
Supplier: Bioss
Description: The features of hemochromatosis include cirrhosis of the liver, diabetes, hypermelanotic pigmentation of the skin, and heart failure. Since hemochromatosis is a relatively easily treated disorder if diagnosed, this is a form of preventable cancer. The HFE protein, which is defective in hereditary hemo-chromatosis, normally is expressed in crypt enterocytes of the duodenum where it has a unique, predominantly intracellular localization. In placenta, the HFE protein co-localizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport. Immunocytochemistry shows that the HFE protein and TfR both are expressed in the crypt enterocytes. Western blots show that, as is the case in human placenta, the HFE protein in crypt enterocytes is physically associated with the TfR and with β2-microglobulin. It is proposed that HFE has two mutually exclusive activities in cells: inhibition of uptake or inhibition of release of iron and that the balance between serum transferrin saturation and serum transferrin-receptor concentrations determines which of these functions predominates. The gene which encodes HFE maps to human chromosome 6p21.3.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12335R-FITC

Anti-HFE Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-12335R-FITC)
Supplier: Bioss
Description: The features of hemochromatosis include cirrhosis of the liver, diabetes, hypermelanotic pigmentation of the skin, and heart failure. Since hemochromatosis is a relatively easily treated disorder if diagnosed, this is a form of preventable cancer. The HFE protein, which is defective in hereditary hemo-chromatosis, normally is expressed in crypt enterocytes of the duodenum where it has a unique, predominantly intracellular localization. In placenta, the HFE protein co-localizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport. Immunocytochemistry shows that the HFE protein and TfR both are expressed in the crypt enterocytes. Western blots show that, as is the case in human placenta, the HFE protein in crypt enterocytes is physically associated with the TfR and with β2-microglobulin. It is proposed that HFE has two mutually exclusive activities in cells: inhibition of uptake or inhibition of release of iron and that the balance between serum transferrin saturation and serum transferrin-receptor concentrations determines which of these functions predominates. The gene which encodes HFE maps to human chromosome 6p21.3.
UOM: 1 * 100 µl
Product Image-BIBB443333

Dropping funnels, cylindrical, without pressure balance

Supplier: SciLabware
Description: Dropping funnel, cylindrical shape, made of Pyrex® borosilicate glass, with cone and socket. Stopcock with interchangeable PTFE key.

Image Unavailable-171-0953

Cartridges for Arium®

Supplier: Sartorius
Description: Filter cartridge, Type: Analytical kit, arium® pro cartridge set for biological, chemical-analytical

Product Image-PRSI30-401

Anti-GMPR2 Rabbit Polyclonal Antibody

Catalog Number: (PRSI30-401)
Supplier: ProSci Inc.
Description: GMPR2 catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. It plays a role in modulating cellular differentiation.
UOM: 1 * 100 µG
Product Image-WITG1.869.250

Dropping funnels, cylindrical, with pressure balance

Supplier: witeg Labortechnik
Description: Dropping funnels, cylindrical, made of borosilicate glass, with needle valve stopcock with PTFE-needle valve.

Image Unavailable-VIVA615DI014

Cartridge for deionisers, arium®

Catalog Number: (VIVA615DI014)
Supplier: Sartorius
Description: Filter cartridge, arium®, Deionisation cartridge with installation kit, capacity range up to 1400 l @ 20 ºdH, flow rate 600 l/h
UOM: 1 * 1 items
Product Image-SIMELI6008

Moisture analysers, profi LIGNO

Supplier: Industrial Physics
Description: profi LIGNO are moisture meters specifically designed for wood and building materials such as screed or gypsum.

Product Image-LONZ02-060F

Serum-free, haematopoietic media, X-VIVO™

Supplier: LONZA
Description: X-VIVO™ chemically defined, serum-free haematopoietic cell media provide nutritionally complete and balanced environments for a variety of cells, including lymphokine activated killer (LAK) cells, peripheral blood lymphocytes (PBL), and tumour infiltrating lymphocytes (TIL).

Product Image-SARTSBLRA025EL-A

Sartobind® Rapid A Labs

Supplier: Sartorius
Description: <p>To affinity and beyond: Fast, flexible and future-proof antibody purification.</p>

New Product

Product Image-HYCLSH30850.02

Dulbecco's phosphate buffered saline (DPBS), ES cell qualified, HyClone™ AdvanceSTEM™

Supplier: HyClone products (Cytiva)
Description: A balanced salt solution tested for use with embryonic stem cells.

Product Image-SARTFT-3-343-047

Filter boards

Supplier: Sartorius
Description: Filter boards are used for filtration of cooking oils, transformer oils and as base paper for impregnation with certain reagents.

Product Image-HEATHS14522

Weighing dishes, aluminium

Catalog Number: (HEATHS14522)
Supplier: HEATHROW
Description: Weighing dishes, made from light gauge aluminium are designed for moisture determination balances. Ideal for general-purpose weighing and dispensing.
UOM: 1 * 50 items
Product Image-512-3304

Forceps for membrane filters

Catalog Number: (512-3304)
Supplier: Sartorius
Description: These filter forceps are made of high grade stainless steel.
UOM: 1 * 1 items
Product Image-50-9985-U025

Anti-PDCD1 Armenian Hamster Monoclonal Antibody (PE (Phycoerythrin)) [clone: J43]

Supplier: Tonbo Biosciences
Description: The J43.1 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein which can co-regulate T cell antigen receptor signaling and therefore modulate T cell activation. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells. PD-1 is a member of a family of receptors including CD28 and CTLA-4 (CD152), which interact with 'B7' ligands to provide a balance of co-stimulatory/co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.

Image Unavailable-BOSSBS-12335R-A680

Anti-HFE/Hemochromatosis Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-12335R-A680)
Supplier: Bioss
Description: The features of hemochromatosis include cirrhosis of the liver, diabetes, hypermelanotic pigmentation of the skin, and heart failure. Since hemochromatosis is a relatively easily treated disorder if diagnosed, this is a form of preventable cancer. The HFE protein, which is defective in hereditary hemo-chromatosis, normally is expressed in crypt enterocytes of the duodenum where it has a unique, predominantly intracellular localisation. In placenta, the HFE protein co-localizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport. Immunocytochemistry shows that the HFE protein and TfR both are expressed in the crypt enterocytes. Western blots show that, as is the case in human placenta, the HFE protein in crypt enterocytes is physically associated with the TfR and with 2-microglobulin. It is proposed that HFE has two mutually exclusive activities in cells: inhibition of uptake or inhibition of release of iron and that the balance between serum transferrin saturation and serum transferrin-receptor concentrations determines which of these functions predominates. The gene which encodes HFE maps to human chromosome 6p21.3.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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