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Image Unavailable-BOSSBS-6337R

Anti-LDLRAP1 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-6337R)
Supplier: Bioss
Description: The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7877R-CY7

Anti-NEDD4 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-7877R-CY7)
Supplier: Bioss
Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7562R-A750

Anti-TIRAP Tyr86 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-7562R-A750)
Supplier: Bioss
Description: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13669R

Anti-TIFA Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-13669R)
Supplier: Bioss
Description: Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6860R

Anti-CASP5 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-6860R)
Supplier: Bioss
Description: Caspase 5 belongs to the Ced3/ICE family of cystein proteases and is an upstream Caspase with a long prodomain. It undergoes a cleavage upon activation, leading to p20 and p10 subunits which have high homology with several other Caspases over the equivalent coding sequences.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-15500R

Anti-LTK Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-15500R)
Supplier: Bioss
Description: LTK is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9746R

Anti-ANKRD20A1 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-9746R)
Supplier: Bioss
Description: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD20A (ankyrin repeat domain-containing protein 20A) is an 823 amino acid protein that contains five ANK repeats. The gene encoding ANKRD20A maps to chromosome 9, which consists of about 145 million bases and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and familial dysautonomia are associated with chromosome 9. Also, chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7562R-FITC

Anti-TIRAP Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-7562R-FITC)
Supplier: Bioss
Description: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11235R-A488

Anti-GRK4, GRK5, GRK6 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-11235R-A488)
Supplier: Bioss
Description: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11235R-CY7

Anti-GRK4, GRK5, GRK6 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-11235R-CY7)
Supplier: Bioss
Description: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11235R-A680

Anti-GRK4, GRK5, GRK6 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (BOSSBS-11235R-A680)
Supplier: Bioss
Description: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalisation, and Signalling events leading to their down-regulation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0026R-A647

Anti-SPP1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-0026R-A647)
Supplier: Bioss
Description: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-1 and is essential in the pathway that leads to type I immunity.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2056R-CY7

Anti-AKT2 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-2056R-CY7)
Supplier: Bioss
Description: IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent. [subcellular location] Cytoplasmic and membrane-associated after cell stimulation leading to its translocation. In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney. Belongs to the Ser/Thr protein kinase family. RAC subfamily.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2056R-CY3

Anti-AKT2 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-2056R-CY3)
Supplier: Bioss
Description: IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent. [subcellular location] Cytoplasmic and membrane-associated after cell stimulation leading to its translocation. In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney. Belongs to the Ser/Thr protein kinase family. RAC subfamily.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2056R-CY5

Anti-AKT2 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-2056R-CY5)
Supplier: Bioss
Description: IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent. [subcellular location] Cytoplasmic and membrane-associated after cell stimulation leading to its translocation. In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney. Belongs to the Ser/Thr protein kinase family. RAC subfamily.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-15542R-CY7

Anti-IDUA Rabbit Polyclonal Antibody (Cy7)

Catalog Number: (BOSSBS-15542R-CY7)
Supplier: Bioss
Description: This gene encodes an enzyme that hydrolyses the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I).
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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