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Image Unavailable-BOSSBS-9366R-A647

Anti-PSMD7 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-9366R-A647)
Supplier: Bioss
Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17.
UOM: 1 * 100 µl
Image Unavailable-ICNA0215869390

Xylene (mixture of isomers), Liquid_clear, colorless ACS

Catalog Number: (ICNA0215869390)
Supplier: MP Biomedicals
Description: Xylene is used as a solvent. It is used in the laboratory to make baths with dry ice to cool reaction vessels, and as a solvent to remove synthetic immersion oil from the microscope objective in light microscopy.
UOM: 1 * 500 mL

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Product Image-640.

Dishes and lids

Supplier: NICKEL ELECTRO
Description: Made of aluminium.

Product Image-444-1022

ThermoMixer® C Thermomixer

Catalog Number: (444-1022)
Supplier: EPPENDORF
Description: The all-in-one for heating/cooling and mixing samples and reactions. The Eppendorf® ThermoMixer C convinces users with its quick and easy-to-exchange SmartBlocks for all common laboratory vessels. There is almost no limit to the variety of applications waiting for you.
UOM: 1 * 1 items

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Image Unavailable-BOSSBS-1372R-HRP

Anti-PSMD9 Rabbit Polyclonal Antibody (HRP (Horseradish PE (Phycoerythrin)rOxidase))

Catalog Number: (BOSSBS-1372R-HRP)
Supplier: Bioss
Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD9 is a non-ATPase subunit of the 19S regulator.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9366R-A488

Anti-PSMD7 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-9366R-A488)
Supplier: Bioss
Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17.
UOM: 1 * 100 µl
Product Image-NICK605/644

Dishes with lid

Catalog Number: (NICK605/644)
Supplier: NICKEL ELECTRO
Description: Aluminium.
UOM: 1 * 1 items
Product Image-BELAF162300000

Multipurpose trays, with lid, SP Bel-Art

Catalog Number: (BELAF162300000)
Supplier: Bel-Art Products, a Part of SP
Description: PP.
UOM: 1 * 1 items
Image Unavailable-ENZOADI905790100

Anti-ETRA Rabbit Polyclonal Antibody

Catalog Number: (ENZOADI905790100)
Supplier: ENZO LIFE SCIENCES
Description: Endothelins are vasoactive peptides that exist in three forms (ET-1, ET-2, and ET-3), and function in the maintenance of vascular tone via two identified seven transmembrane-spanning domain-containing G protein-coupled receptors (GPCR), endothelin A (ETA) and endothelin B (ETB). The human ETA receptor is primarily expressed in vascular smooth muscle cells, including those of the heart (also in myocytes), lung, and brain, and its stimulation generally results in vasoconstriction. Activation of ETA receptors can be stimulated by binding of ET-1 and ET-2, but not ET-3. triggering the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells. Human ETB receptors are primarily expressed in endothelial cells lining the vessel walls of the lungs, heart, and brain, and in contrast to ETA receptors, stimulation generally results in transient vasodilation. Activation of ETB receptors can be stimulated by binding of all three endothelins, triggering the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells. Both ETA and ETB receptors signal primarily via coupling to Gq/11 alpha subunits, although Gi/o and Gs coupling are also established mechanisms of endothelin signaling, resulting in stimulation of phospholipases C, A2, and D.
UOM: 1 * 100 µG

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Image Unavailable-KGWA78212669

Accessories for Liquid Nitrogen Containers, Type APOLLO

Supplier: KGW
Description: Cryogenics Storage Vessel, Level indicator WIKA

Product Image-THARJC800-30

Automated stainer, Cellstain® 23

Catalog Number: (THARJC800-30)
Supplier: THARMAC GmbH
Description: The CellStain 23 features programming unit for individually adjustable steps in staining, rinsing and drying stations and implements of different stainings due to forwards and backwards movement of slide holder. It contains storage place for 20 staining programs up to 30 steps each with password protected access.
UOM: 1 * 1 items
Product Image-LAMA1884

Crates with lid

Supplier: LAMAPLAST
Description: PP, white, stackable.

Product Image-BARN88882008

Thermo Scientific™ Digital Mini Rotator

Catalog Number: (BARN88882008)
Supplier: Thermo Fisher Scientific
Description: Provides smooth, accurate and orbital mixing of various vessels in the laboratory.
UOM: 1 * 1 items
Product Image-KGWA2517

Liquid nitrogen storage vessels, type ALU

Supplier: KGW
Description: These containers are made from light aluminium with compound materials in the neck range and has super insolation foil in the vacuum space.

Image Unavailable-BOSSBS-8546R-CY7

Anti-KRIT1 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (BOSSBS-8546R-CY7)
Supplier: Bioss
Description: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8546R

Anti-KRIT1 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-8546R)
Supplier: Bioss
Description: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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