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Image Unavailable-478-0416

Accessories for liquid nitrogen cylinders, XL series liquid gas

Supplier: TAYLOR WHARTON
Description: Cryogenic storage vessel, Transfer hose, 1.2 m

Product Image-BCISBCS-517

Accessories for liquid nitrogen transport carrier, CryoPod™

Catalog Number: (BCISBCS-517)
Supplier: BIOCISION
Description: Cryogenics Storage Vessel, CryoPod™ LN<sub>2</sub> absorbent pads (4/pack)
UOM: 1 * 1 items

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Image Unavailable-BOSSBS-8546R-FITC

Anti-KRIT1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (BOSSBS-8546R-FITC)
Supplier: Bioss
Description: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8546R-A350

Anti-KRIT1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Catalog Number: (BOSSBS-8546R-A350)
Supplier: Bioss
Description: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9346R

Anti-Proteasome 19S 10B Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-9346R)
Supplier: Bioss
Description: The 26S proteasome is a large complex involved in the intracellular degradation of proteins in eukaryotes. Ubiquitination by E3 ubiquitin ligases targets proteins for degradation by this complex. The 26S proteasome plays an important role in the regulation of many biological processes. It is composed of over 30 different subunits and contains at least two copies of each subunit. Assembly of this large complex is ATP-dependent. Due to its size, it is fairly unstable and often disassociates into subcomplexes (including a 20S core and two 19S regulatory complexes). The 26s proteasome p42A (also known as Rpn7 in yeast and S10 in human) is one of at least nine, non-ATPase lid subunits of the 19S regulatory complex. It is important in the proper assembly and stability of the 26S proteasome. The 19S regulatory complex recognizes ubiquitinated proteins, removes the ubiquitin chains and translocates the proteins to the 20S core for degradation.
UOM: 1 * 100 µl
Product Image-478-3115

Liquid nitrogen storage vessels, TR

Supplier: Air Liquide
Description: Range of non-pressurised vessels used to store and transport liquid nitrogen.

Product Image-478-0804

Cryogenic vessel, Bio-Cane®

Supplier: Thermo Fisher Scientific
Description: Cryogenic vessels are ideal to store cells, tissues and biologicals in an economical and biological manner.

Product Image-HERA4000290

Accessories for cryogenic supply tank, LN₂

Supplier: Thermo Fisher Scientific
Description: Cryogenics Storage Vessel, LN₂ Cylinder roller base for LN₂ supply tank

Image Unavailable-IKAA20112966

Accessories for magnetic stirrers, TWISTER

Supplier: IKA
Description: Magnetic Stirrer, Vessel holder for glass containers with Ø 23 mm

Product Image-478-0455

Accessories for liquid nitrogen dewars

Supplier: TAYLOR WHARTON
Description: Cryogenic storage vessel, Roller base

Image Unavailable-BOSSBS-6627R

Anti-PSMC1 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-6627R)
Supplier: Bioss
Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.
UOM: 1 * 100 µl
Product Image-BARNCV509X51

Accessories for Cryogenic Rack and Box Systems, Locator™, BARN

Supplier: Thermo Fisher Scientific
Description: Cryogenics storage vessel accessory, CryoClaw

Product Image-SAMPA179-50

Bottles, Aluminium, with tamper evident lid

Supplier: Sampling Systems
Description: Aluminium bottles are very popular in general laboratory and production work.

Product Image-IKAA20113438

Reactor systems, EasySyn

Supplier: IKA
Description: EasySyn is the reactor system for organic or aqueous syntheses, and the only reactor system for which you can get all the complementary components from a single source: Overhead stirrers, circulators, vacuum pumps and controllers, sensors and automation software. All from IKA and all perfectly matched to each other. With its double-walled reactor vessels from 500 to 5000 ml, EasySyn is a medium-sized and very flexible upscaling system. It ensures safe and reproducible chemical reactions.

Product Image-HERA4000371

Accessories for CryoPlus™ LN₂ storage system

Supplier: Thermo Scientific
Description: Cryogenics Storage Vessel, CryoPlus™, Cardboard divider, 5 ml capacity, 100-cell

Product Image-734-1817

Sterile containers, 250 ml, Corning®

Supplier: Corning
Description: PP Container, transparent, with snap-on HDPE lid.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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