You Searched For: MPLA

Supplier: Biorbyt

Description: Anti-APLN Rabbit Polyclonal Antibody

Catalog Number: (BIRBORB73761-100)

Supplier: Biorbyt

Description: Anti-BTLA Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

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Catalog Number: (PRSI91-510)

Supplier: ProSci Inc.

Description: B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.

UOM: 1 * 50 µG

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Catalog Number: (BIRBORB77287-100)

Supplier: Biorbyt

Description: Anti-APLN Rabbit Polyclonal Antibody

UOM: 1 * 100 µG

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Catalog Number: (BIRBORB114444-100)

Supplier: Biorbyt

Description: Anti-APLN Rabbit Polyclonal Antibody (Cy3®)

UOM: 1 * 100 µl

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Catalog Number: (BIRBORB123469-100)

Supplier: Biorbyt

Description: Anti-APLN Rabbit Polyclonal Antibody (Cy7®)

UOM: 1 * 100 µl

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Catalog Number: (ABNOH00008862-AP42)

Supplier: Abnova

Description: This Set comes with matched Antibody Pair to detect and quantify protein level of human APLN.

UOM: 1 * 1 SET

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Catalog Number: (BOSSBS-12489R-FITC)

Supplier: Bioss

Description: APLF is a 511 amino acid protein that contains one FHA doman and two C2H2type zinc fingers. Localized to both the nucleus and the cytoplasm, APLF interacts with XRCC1, XRCC4 and Ku-86 and, via these interactions, is involved in single-strand and double-strand DNA break repair. APLF is subject to post-translational phosphorylation in response to DNA breaks. The gene encoding APLF maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-12489R-HRP)

Supplier: Bioss

Description: APLF is a 511 amino acid protein that contains one FHA doman and two C2H2type zinc fingers. Localized to both the nucleus and the cytoplasm, APLF interacts with XRCC1, XRCC4 and Ku-86 and, via these interactions, is involved in single-strand and double-strand DNA break repair. APLF is subject to post-translational phosphorylation in response to DNA breaks. The gene encoding APLF maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-0624R-A488)

Supplier: Bioss

Description: B and T lymphocyte attenuator (BTLA), an immunoglobulin domain-containing glycoprotein with two immunoreceptor tyrosine-based inhibitory motifs. BTLA is not expressed by naive T cells, but it is induced during activation and remains expressed on T helper type 1 (T(H)1) but not T(H)2 cells. Crosslinking BTLA with antigen receptors induces its tyrosine phosphorylation and association with the Src homology domain 2 (SH2)-containing protein tyrosine phosphatases SHP-1 and SHP-2, and attenuates production of interleukin 2 (IL-2). BTLA-deficient T cells show increased proliferation, and BTLA-deficient mice have increased specific antibody responses and enhanced sensitivity to experimental autoimmune encephalomyelitis. B7x, a peripheral homolog of B7, is a ligand of BTLA. Thus, BTLA is a third inhibitory receptor on T lymphocytes with similarities to cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed death 1 (PD-1).

UOM: 1 * 100 µl

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Catalog Number: (BOSSBS-2425R-FITC)

Supplier: Bioss

Description: Apelin is a neuropeptide expressed in the supraoptic and paraventricular nuclei and is an endogenous ligand for APJ, a G protein-coupled orphan receptor which is an alternative coreceptor with CD4 for HIV-1. Apelin and APJ are ubiquitously expressed in peripheral tissues, with highest levels reported for heart and lungs, as well several regions within the central nervous system. The actions of apelin remain largely unknown: Apelin inhibits HIV-1 entry in cells coexpressing CD4 and APJ; the oral intake of Apelin in colostrum and breast milk could have a role in the modulation of the immune responses in neonates; more recent studies have also indicated a role for Apelin in the central control of body fluid homeostasis, by influencing AVP release and drinking behavior. In the cardiovascular system several actions of Apelin have been described, including endothelium-dependent vasodilatation, vasoconstriction through direct action on smooth muscle and positive inotropism.

UOM: 1 * 100 µl

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Supplier: Bohlender

Description: PTFE, white. For connecting tubes or tubing to vessels with ground joint. For inserting and fixing probes, thermometers, dip tubes or cables.

Supplier: Bohlender

Description: Adapter with screw fitting made from PPS, cone joint body made from PTFE.

Catalog Number: (BIRBORB114936-100)

Supplier: Biorbyt

Description: Anti-APLN Rabbit Polyclonal Antibody (Cy5®)

UOM: 1 * 100 µl

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Supplier: Bohlender

Description: PTFE/Glass fibre, PBTP or PPS.

Catalog Number: (BOSSBS-2425R-A647)

Supplier: Bioss

Description: Apelin is a neuropeptide expressed in the supraoptic and paraventricular nuclei and is an endogenous ligand for APJ, a G protein-coupled orphan receptor which is an alternative coreceptor with CD4 for HIV-1. Apelin and APJ are ubiquitously expressed in peripheral tissues, with highest levels reported for heart and lungs, as well several regions within the central nervous system. The actions of apelin remain largely unknown: Apelin inhibits HIV-1 entry in cells coexpressing CD4 and APJ; the oral intake of Apelin in colostrum and breast milk could have a role in the modulation of the immune responses in neonates; more recent studies have also indicated a role for Apelin in the central control of body fluid homeostasis, by influencing AVP release and drinking behavior. In the cardiovascular system several actions of Apelin have been described, including endothelium-dependent vasodilatation, vasoconstriction through direct action on smooth muscle and positive inotropism.

UOM: 1 * 100 µl

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