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Product Image-PRSI6299

Anti-SIK1 Rabbit Polyclonal Antibody

Catalog Number: (PRSI6299)
Supplier: ProSci Inc.
Description: SIK1 Antibody: Salt-inducible kinase 1 (SIK1), also known as SNF1LK or MSK, plays a role in histone modification and G2/M cell cycle regulation. It is a 783 amino acid protein that contains one UBA domain and belongs to the Ser/Thr protein kinase family (AMPK subfamily). Localized to both the nucleus and the cytoplasm, SIK1 is a class II HDAC kinase that uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be important for the early stages of skeletal muscle growth and myocardial cell differentiation.
UOM: 1 * 100 µG
Product Image-PRSI7393

Anti-LPIN1 Rabbit Polyclonal Antibody

Catalog Number: (PRSI7393)
Supplier: ProSci Inc.
Description: LPIN1 Antibody: LPIN1, also known as PAP1, is a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol . LPIN1 is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism (1,2). Mutations in LPIN1 are associated with metabolic diseases such as type 2 diabetes and recurrent acute myoglobinuria (3,4) and it is also a candidate for several human lipodystrophy syndromes.
UOM: 1 * 100 µG
Product Image-141-0552

Water softener, Aqua-Soft-System, PG 8597

Catalog Number: (141-0552)
Supplier: MIELE
Description: The Aqua-Soft system provides a continual supply of soft water and is suitable for water with a hardness up to 71° dH. It operates as a level controlled two-tank system, consisting of two cartridges with ion exchange resins and a salt reservoir. The resins are enriched with sodium ions. The hard water flows over the resins in the first cartridge, where calcium and magnesium ions are exchanged for sodium ions. At this time, no water is flowing through the second cartridge. When one cartridge is exhausted, the water is routed to the second cartridge by means of a hardness level selector corresponding to the hardness of the local water, which is inserted by customer service when the device is used for the first time. At the same time, the regeneration of the resins from the exhausted container is activated. For this treatment, brine (NaCl) is drawn from the salt reservoir. The reservoir must be replenished regularly with coarse salt pellets. Fill quantity approx. 25 kg.
UOM: 1 * 1 items
Image Unavailable-PRSI91-126

Human Recombinant Grancalcin (from E. coli)

Catalog Number: (PRSI91-126)
Supplier: ProSci Inc.
Description: Grancalcin (GCA) is a member of the penta EF hand subfamily which includes sorcin, calpain and ALG2. Grancalcin is highly expressed bone marrow and also can detected in neutrophils and macrophages. Grancalcin interacts with L-plastin which known to have actin bundling activity. It indicates that Grancalcin may play an important role in the adhesion of neutrophils to fibronectin. Furthermore, Grancalcin localization is dependent upon calcium and magnesium. It associates with both the granule and membrane fractions, which suggested a role for grancalcin in granule-membrane fusion and degranulation.
UOM: 1 * 50 µG
Product Image-549-0769

QuEChERS extraction products

Supplier: Thermo Fisher Scientific
Description: The QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) technique is increasingly becoming the technique of choice for the extraction of pesticide residues in fruit, vegetables and other foods. The QuEChERS method offers the advantage of high recoveries, accurate results and high sample throughput, combined with the associated cost savings with low solvent and labour requirements. Yet the procedure is robust and rugged.

Product Image-K9021

Master mixes, DreamTaq™ Hot Start PCR master mix (2X)

Supplier: Thermo Fisher Scientific
Description: Thermo Scientific™ DreamTaq™ Hot Start PCR Master Mix is a ready to use 2X reaction mix that includes DreamTaq™ Hot Start DNA Polymerase, DreamTaq™ buffer, magnesium, and dNTPs. The master mix allows easy reaction setup with fewer pipetting steps, with only primers, template, and water needing to be added. The green master mix includes density reagent and two tracking dyes for convenient direct loading of PCR products on a gel.

Image Unavailable-PRSI33-898

Anti-TOP1MT Mouse Monoclonal Antibody [clone: TPIMT-1]

Catalog Number: (PRSI33-898)
Supplier: ProSci Inc.
Description: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
UOM: 1 * 100 µG

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Image Unavailable-PRSI33-332

Anti-TOP1MT Mouse Monoclonal Antibody [clone: TOP1MT/488]

Catalog Number: (PRSI33-332)
Supplier: ProSci Inc.
Description: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
UOM: 1 * 100 µG

New Product


Product Image-PRSI6287

Anti-ATP2C1 Rabbit Polyclonal Antibody

Catalog Number: (PRSI6287)
Supplier: ProSci Inc.
Description: ATP2C1 Antibody: ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.
UOM: 1 * 100 µG
Image Unavailable-ICNA0215533691

Manganese(II) sulphate monohydrate, pale pink powder

Supplier: MP Biomedicals
Description: Magnesium sulphate is used as a colorant in dyes and red glazes for porcelain. As a trace essential element it is a nutritional factor for all animals; often a supplement in feed. It is used in biological assays to study the effects of manganese on the central nervous system, and to assess exposure limits.

Product Image-PRSI6289

Anti-ATP2C2 Rabbit Polyclonal Antibody

Catalog Number: (PRSI6289)
Supplier: ProSci Inc.
Description: ATP2C2 Antibody: ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
UOM: 1 * 100 µG
Product Image-HEWL5982-5550CH

QuEChERS extraction kits

Supplier: Agilent
Description: Step 1: Extraction
Choose the extraction salt packet based on your method of analysis, AOAC or EN. The buffered extraction salts are amenable for more liable pesticides. Adding solvent and then salts to a comminuted fruit or vegetable sample (10 g or 15 g) enables you to extract the pesticides of interest into the organic layer. However, adding a food sample with a high percentage of water directly to the salts may create an exothermic reaction that can affect your analyte recoveries.

Product Image-HEWL5982-5258CH

QuEChERS dispersive kits

Catalog Number: (HEWL5982-5258CH)
Supplier: Agilent
Description: Step 2: Dispersive SPE cleanup
Select the dispersive SPE kit suited to the type of food being analysed and the method you are following. In this step, an aliquot of the sample extract from step one (see QuEChERS extraction kits) is added to a 2 or 15 ml centrifuge tube containing a small amount of SPE sorbent and MgSO₄. The sorbent will pull out interfering matrix materials from the sample, while the MgSO₄ helps remove excess water and improve analyte partitioning.
UOM: 1 * 1 items
Product Image-ICNA091760420

Phosphate Buffered Salts, Dulbecco's Formula, without Magnesium and Calcium, MP Biomedicals

Supplier: MP Biomedicals
Description: Role of a balanced salt solution in cell culture is multifaceted and can be divided into four principal functions: 1. Serves as an irrigating, transporting and diluting fluid while maintaining intra- and extracellular osmotic balance; 2. Provides cells with water and certain bulk inorganic ions essential for normal cell metabolism; 3. Combined with a carbohydrate, such as glucose, provides the principal energy source for cell metabolism; 4. Provides a buffering system to maintain the medium within the physiological pH range (7,2 to 7,6).

Image Unavailable-P8119-5ML

Supelco® Organic Reference Standard, Protein Standard

Catalog Number: (P8119-5ML)
Supplier: Merck
Description: Organic Standard, Protein standard
UOM: 1 * 5 mL
Image Unavailable-18179-25MG

Supelco® Organic Reference Standard, Pullulan Standard

Catalog Number: (18179-25MG)
Supplier: Merck
Description: GPC Standard, Pullulan Standard
UOM: 1 * 25 mg

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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