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Anti-C1orf187 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (BOSSBS-15047R-CY3)
Supplier: Bioss
Description: C1orf187, also known as Draxin, Dorsal repulsive axon guidance protein and Neucrin, is a 349 amino acid secreted protein that is required of the development of the spinal cord and forebrain commissures. C1orf187 acts as a chemorepulsive guidance protein and directs commissural axons during development by repelling neurite outgrowth from the spinal cord. During development, C1orf187 modulates neural crest migration by reducing the polarization of these cells, leading to reduced velocity of migration and increased frequency of changing direction, leading to a net decrease in migrational distance. It acts as an antagonist of the Wnt signaling pathway by inhibiting the stabilization of cytosolic _-catenin via its interaction with LRP6. C1orf187 inhibits outgrowth from the olfactory bulb and likely contributes to the formation of the lateral olfactory tract.
UOM: 1 * 100 µl
Product Image-BRND23400

Accessories for compact automatic burettes

Catalog Number: (BRND23400)
Supplier: Brand
Description: Burette, Single bulb rubber bellows, orange coloured, with valve and tubing
UOM: 1 * 1 items
Product Image-631-0738

VWR®, Slide Boxes

Supplier: VWR Collection
Description: Slide boxes for holding standard microscopy slides.

Product Image-PRTWPA54BKR

Tactical flashlight, PA54

Catalog Number: (PRTWPA54BKR)
Supplier: Portwest
Description: Strong and durable precision engineered aluminium shell torch, uses new CREE technology which is up to 10 times brighter than current L.E.D bulbs.
UOM: 1 * 1 items
Image Unavailable-BOSSBS-11861R-A647

Anti-KALRN Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (BOSSBS-11861R-A647)
Supplier: Bioss
Description: HAP1 (huntingtin-associated protein 1) binds to huntingtin (1). Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington’s disease (HD) (2,3). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1). HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4,5). HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem (1). Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons (6). Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13522R

Anti-GPR4 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-13522R)
Supplier: Bioss
Description: G protein-coupled receptors (GPRs or GPCRs), also known as seven transmembrane receptors, heptahelical receptors, or 7TM receptors, are members of the largest protein family and play a role in many different stimulus-response pathways. G-protein coupled receptors mediate extracellular signals into intracellular signals (G-protein activation). They respond to a great variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GPR proteins are integral seven-pass membrane proteins with some conserved amino acid regions. GPR19, an orphan receptor, shows elevated expression during embyronic development of the nervous sytem as well as in specific regions of adult mouse brain, including the olfactory bulb, the hippocampus, hypothalamic nuclei and the cerebellum. The GPR19 gene maps to a location on chromosome 12, which is a frequent target for rearrangement in cancer cells and involved in childhood acute lymphoblastic leukemia (ALL).
UOM: 1 * 100 µl
Image Unavailable-UVPA38-0154-01

Accessories for UV rechargeable lamps

Supplier: UVP ULTRA VIOLET PRODUCTS
Description: Replacement filter, For: Rechargeable lamp, UVSL-26P

Image Unavailable-ZEIS4310309120000

Accessories for Inverted Digital Microscope, Axiovert 5

Supplier: ZEISS
Description: Accessory for microscopes, Microscope stand Axiovert 5 TL

New Product

Image Unavailable-UVPA34-0010-01

Accessories for UV fraud detection lamps

Catalog Number: (UVPA34-0010-01)
Supplier: UVP ULTRA VIOLET PRODUCTS
Description: Replacement UV tube, longwave, BLB, For: SL-2M
UOM: 1 * 1 items
Image Unavailable-BOSSBS-11072R-A488

Anti-ASTN2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Catalog Number: (BOSSBS-11072R-A488)
Supplier: Bioss
Description: Neuronal migration of the central nervous system is a specialized form of cell motility that takes place in the laminar structure of the cortical regions of brain. Astrotactin is a neuronal cell surface protein expressed on postmitotic neuronal precursors in the cerebellum, hippocampus, cerebrum, and olfactory bulb. Astrotactin 2 is a paralog of Astrotactin. Astrotactin mediates neuron-astroglial interactions and is also implicated in synaptic development as well as many other neuronal activities. Astrotactin has three epidermal growth factor repeat domains and two fibronectin type III repeat domains. The human Astrotactin gene shows extensive homology to the mouse Astrotactin gene. Mutations in the Astrotactin gene are linked to neuronal migration defects in both species.
UOM: 1 * 100 µl
Product Image-IDCPMSAH352

Accessories

Supplier: Dino-Lite / IDCP B.V.
Description: Accessory for handheld microscope, Handle (HDE-01) for EarScope microscopes, lightweight aluminum, for a more ergonomic and natural grip

Image Unavailable-630-1258

Accessories for TM 3000 tabletop electron microscopes

Catalog Number: (630-1258)
Supplier: HITACHI HIGH TECHNOLOGIES EURO
Description: Accessory for microscopes, For: TM 3000 table top electron microscope, Tungsten filament
UOM: 1 * 10 items
Image Unavailable-BOSSBS-10392R-HRP

Anti-SYNGAP Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (BOSSBS-10392R-HRP)
Supplier: Bioss
Description: The PSD-95/SAP 90 family of proteins, which are known to bind to and cluster various membrane proteins, are involved in the organization of synaptic structure. SynGAP (for synaptic GTPase activating protein), a novel synaptic RasGAP, is a brain-specific protein abundant in the cortex, hippocampus and olfactory bulb. SynGAP interacts with all three PDZ domains within PSD-95/ SAP 90 proteins. It represents one of three classes of mammalian RasGAPs and is specifically localized to excitatory synapses possessing NMDA receptors. SynGAP may be involved in the regulation of BDNF as well as Ras signaling. Its activity is inhibited by phosphorylation by CaMKII, which could result in the activation of the MAP kinase pathway.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-15047R

Anti-C1orf187 Rabbit Polyclonal Antibody

Catalog Number: (BOSSBS-15047R)
Supplier: Bioss
Description: C1orf187, also known as Draxin, Dorsal repulsive axon guidance protein and Neucrin, is a 349 amino acid secreted protein that is required of the development of the spinal cord and forebrain commissures. C1orf187 acts as a chemorepulsive guidance protein and directs commissural axons during development by repelling neurite outgrowth from the spinal cord. During development, C1orf187 modulates neural crest migration by reducing the polarization of these cells, leading to reduced velocity of migration and increased frequency of changing direction, leading to a net decrease in migrational distance. It acts as an antagonist of the Wnt signaling pathway by inhibiting the stabilization of cytosolic β-catenin via its interaction with LRP6. C1orf187 inhibits outgrowth from the olfactory bulb and likely contributes to the formation of the lateral olfactory tract.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13597R-A750

Anti-HESX1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (BOSSBS-13597R-A750)
Supplier: Bioss
Description: The homeobox protein, HESX1, which is also known as Rathke?s pouch homeobox, HANF, homeodomain transcription factor, and anterior-restricted homeobox protein is a transcription factor that belongs to the homeodomain family of DNA binding proteins. HESX1 is initially expressed in embryonic stem cells and the primitive forebrain, and is essential for normal development of the eyes and other anterior CNS structures, such as the hypothalamus, the pituitary gland and the olfactory bulbs. The homeobox gene Hesx1 is expressed in the anterior visceral endoderm (AVE), anterior axial mesendoderm (AME), and anterior neural ectoderm (ANE) during early embryogenesis. Mutations in the Hesx1 gene are associated with disorders that are comparable with septo-optic dysplasia (SOD). These disorders are characterised by hypoplasia of the optic nerve, various types of forebrain defects and pituitary hormone deficiencies, including hypothyroidism. Hesx1 also acts as a transcriptional repressor of reporter gene constructs in tissue culture assays.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11861R-CY5

Anti-KALRN Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (BOSSBS-11861R-CY5)
Supplier: Bioss
Description: HAP1 (huntingtin-associated protein 1) binds to huntingtin (1). Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington’s disease (HD) (2,3). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1). HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4,5). HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem (1). Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons (6). Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.
UOM: 1 * 100 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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