Print…

You Searched For: PD+169316


1 525  results were found

Refine Results Sort by
SearchResultCount:"1525"

Sort Results

List View Easy View

Rate These Search Results

Image Unavailable-PRSI91-596

Human recombinant PDCD1 (from cells)

Catalog Number: (PRSI91-596)
Supplier: ProSci Inc.
Description: Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN- gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
UOM: 1 * 50 µG
Image Unavailable-PRSI92-673

Human recombinant PDCD1 (from cells)

Catalog Number: (PRSI92-673)
Supplier: ProSci Inc.
Description: Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN- gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
UOM: 1 * 50 µG
Product Image-PRSI50-241

Anti-SNCA Rabbit Polyclonal Antibody

Catalog Number: (PRSI50-241)
Supplier: ProSci Inc.
Description: Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Mutation of the alpha-synuclein gene is associated with familial forms of PD (Newmann et al., 2002). Recent evidence suggests that phosphorylation of alpha-synuclein at ser129 plays a role in the formation of inclusions in PD (Smith et al., 2005; Masliah et al., 2005).
UOM: 1 * 100 µl
Image Unavailable-20-5984-T025

APC Anti-Human CD274 PD-L1 (B7-H1) (29E.2A3) 1 * 25 Tests

Catalog Number: (20-5984-T025)
Supplier: Tonbo Biosciences
Description: APC Anti-Human CD274 PD-L1 (B7-H1) (29E.2A3) 1 * 25 Tests
UOM: 1 * 25 Tests
Image Unavailable-60-1243-U025

PE-Cyanine7 Anti-Mouse CD274 (PD-L1, B7-H1) (10F.9G2) 1 * 25 G

Catalog Number: (60-1243-U025)
Supplier: Tonbo Biosciences
Description: PE-Cyanine7 Anti-Mouse CD274 (PD-L1, B7-H1) (10F.9G2) 1 * 25 G
UOM: 1 * 25 µG
Image Unavailable-PRSI92-671

Human recombinant PDL1 (from cells)

Catalog Number: (PRSI92-671)
Supplier: ProSci Inc.
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumour growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
UOM: 1 * 50 µG
Image Unavailable-65-5984-T025

PerCP-Cyanine5.5 Anti-Human CD274 PD-L1 (B7-H1) (29E.2A3) 1 * 25 Tests

Catalog Number: (65-5984-T025)
Supplier: Tonbo Biosciences
Description: PerCP-Cyanine5.5 Anti-Human CD274 PD-L1 (B7-H1) (29E.2A3) 1 * 25 Tests
UOM: 1 * 25 Tests
Image Unavailable-65-5984-T100

PerCP-Cyanine5.5 Anti-Human CD274 PD-L1 (B7-H1) (29E.2A3) 1 * 100 Tests

Catalog Number: (65-5984-T100)
Supplier: Tonbo Biosciences
Description: PerCP-Cyanine5.5 Anti-Human CD274 PD-L1 (B7-H1) (29E.2A3) 1 * 100 Tests
UOM: 1 * 100 Tests
Image Unavailable-PRSI76-954

Anti-Pdcd1lg2 Rat Monoclonal Antibody [clone: TY25]

Catalog Number: (PRSI76-954)
Supplier: ProSci Inc.
Description: The TY25 antibody reacts with mouse B7-DC (PD-L2), a 42 kDa glycoprotein of the B7 family of the immunoglobulin superfamily. B7-DC is expressed by macrophages, monocytes, and sub-populations of dendritic cells. B7-DC has similarities with the rest of the B7 family, but it does not bind to CD28/CD152. The receptor for B7-DC is PD-1, which contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM), and is expressed on activated B and T cells. The interaction between B7-DC and its receptor seems to downregulate immune responses. However, B7-DC seems to be a costimulator of T lymphocytes, reacting with a receptor different than PD-1. B7-DC can bind and stimulate dendritic cells. It is also the first B-7 ligand involved in bidirectional communication. The TY25 monoclonal antibody blocks the binding of B7-DC to its receptor (PD-1) and can be used for studying the interaction between the antigen presenting cells and T lymphocytes.
UOM: 1 * 0,1 mg
Image Unavailable-PRSI92-625

Human recombinant PDL1 (from cells)

Catalog Number: (PRSI92-625)
Supplier: ProSci Inc.
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumour growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
UOM: 1 * 50 µG
Image Unavailable-PRSI91-293

Human recombinant PDL1 (from cells)

Catalog Number: (PRSI91-293)
Supplier: ProSci Inc.
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
UOM: 1 * 50 µG
Image Unavailable-PRSI92-599

Human recombinant PDL1 (from cells)

Catalog Number: (PRSI92-599)
Supplier: ProSci Inc.
Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumour growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
UOM: 1 * 50 µG
Image Unavailable-GENSZ03371-1

Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1), is a protein that in humans is encoded by the CD274 gene. PD-L1 is a 40 kDa type 1 transmembrane protein that has been speculated t 1 * 1 mg

Catalog Number: (GENSZ03371-1)
Supplier: Genscript
Description: <b>Programmed death-ligand 1 (PD-L1)</b> also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1), is a protein that in humans is encoded by the CD274 gene. PD-L1 is a 40 kDa type 1 transmembrane protein that has been speculated t 1 * 1 mg
UOM: 1 * 1 mg
Image Unavailable-GENSZ03371-50

Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1), is a protein that in humans is encoded by the CD274 gene. PD-L1 is a 40 kDa type 1 transmembrane protein that has been speculated t 1 * 50 µG

Catalog Number: (GENSZ03371-50)
Supplier: Genscript
Description: <b>Programmed death-ligand 1 (PD-L1)</b> also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1), is a protein that in humans is encoded by the CD274 gene. PD-L1 is a 40 kDa type 1 transmembrane protein that has been speculated t 1 * 50 µG
UOM: 1 * 50 µG
Image Unavailable-PRSI90-430

Human recombinant CD274 non-lytic (from CHO cells)

Catalog Number: (PRSI90-430)
Supplier: ProSci Inc.
Description: Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. CD274 has been identified as one of two ligands for programmed death 1 (PD-1), a member of the CD28 family of immunoreceptors. CD274 is widely expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. CD274 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. CD274 expression is also induced in dendritic cells and keratinocytes after IFN-gamma stimulation. CD274 expression is also upregulated in a variety of tumour cell lines. Interaction of CD274 with PD-1 results in inhibition of TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. The CD274 - PD-1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.
UOM: 1 * 100 µG
Image Unavailable-PRSI90-432

Mouse recombinant CD274 non-lytic (from CHO cells)

Catalog Number: (PRSI90-432)
Supplier: ProSci Inc.
Description: Programmed death ligand 1 (PD-L1, B7-H1 or CD274) is a member of the growing B7 family of immune proteins that provide signals for both stimulating and inhibiting T cell activation. CD274 has been identified as one of two ligands for programmed death 1 (PD-1), a member of the CD28 family of immunoreceptors. CD274 is widely expressed in several organs such as heart, skeletal muscle, placenta and lung, and in lower amounts in thymus, spleen, kidney and liver. CD274 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. CD274 expression is also induced in dendritic cells and keratinocytes after IFN-gamma stimulation. CD274 expression is also upregulated in a variety of tumour cell lines. Interaction of CD274 with PD-1 results in inhibition of TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. The CD274 - PD-1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.
UOM: 1 * 100 µG
Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
833 - 848 of 1 525
no targeter for Bottom