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Supplier: Tonbo Biosciences
Description: The 3G3 antibody reacts with mouse Foxp3, a 50-55 kDa transcription factor which is a central regulator of T cell activity and is critical for the development and function of regulatory T cells (Tregs). Foxp3 is expressed at constitutively high levels in Treg cells, which are further identified as being CD4+ CD25+. In resting conventional T cells (CD4+ CD25-) Foxp3 expression is restricted, and upon TCR activation is expressed only transiently and in a small proportion of cells. However, the growth factor TGF-beta has been shown to induce expression of Foxp3 in naïve T cells, driving their development into Foxp3+ Tregs, which are called “induced” or “adaptive” Tregs. These cells are phenotypically similar to so-called “natural” Tregs (CD4+ CD25high Foxp3+) which originate in the thymus and comprise the majority of Treg cells. Tregs are critical for maintaining peripheral tolerance and are implicated in the development of autoimmunity. It is important to review the literature in choosing an antibody for the Foxp3 antigen in flow cytometry, as the potential for high background or non-specific staining may be observed. The 3G3 antibody may be used for intracellular detection of Foxp3 in cells from mouse and Rhesus macaque.

Catalog Number: (BOSSBS-4013R-CY7)
Supplier: Bioss
Description: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
UOM: 1 * 100 µl


Catalog Number: (AATB2582)
Supplier: AAT BIOQUEST
Description: PE-Cy7 is a popular color used in flow cytometry.
UOM: 1 * 1 mg


Catalog Number: (BIRBORB131089-100)
Supplier: Biorbyt
Description: Anti-PGR Rabbit Polyclonal Antibody (PE (Phycoerythrin)/Cy7®)
UOM: 1 * 100 µl

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Catalog Number: (BIRBORB131138-100)
Supplier: Biorbyt
Description: Anti-Syncytin 1 Rabbit Polyclonal Antibody (PE (Phycoerythrin)/Cy7®)
UOM: 1 * 100 µl

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Catalog Number: (BIRBORB131140-100)
Supplier: Biorbyt
Description: Anti-TBX3 Rabbit Polyclonal Antibody (PE (Phycoerythrin)/Cy7®)
UOM: 1 * 100 µl

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Catalog Number: (BIRBORB130904-100)
Supplier: Biorbyt
Description: Anti-GCG Rabbit Polyclonal Antibody (PE (Phycoerythrin)/Cy7®)
UOM: 1 * 100 µl

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Catalog Number: (BIRBORB130752-100)
Supplier: Biorbyt
Description: Anti-BrdU Rabbit Polyclonal Antibody (PE (Phycoerythrin)/Cy7®)
UOM: 1 * 100 µl

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Catalog Number: (BIRBORB130881-100)
Supplier: Biorbyt
Description: Anti-F-Actin Rabbit Polyclonal Antibody (PE (Phycoerythrin)/Cy7®)
UOM: 1 * 100 µl

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Catalog Number: (BIRBORB130739-100)
Supplier: Biorbyt
Description: Anti-ADRB1 Rabbit Polyclonal Antibody (PE (Phycoerythrin)/Cy7®)
UOM: 1 * 100 µl

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Catalog Number: (BIRBORB130899-100)
Supplier: Biorbyt
Description: Anti-Galanin Mouse Polyclonal Antibody (PE (Phycoerythrin)/Cy7®)
UOM: 1 * 100 µl

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Catalog Number: (BIRBORB130961-100)
Supplier: Biorbyt
Description: Anti-INS Rabbit Polyclonal Antibody (PE (Phycoerythrin)/Cy7®)
UOM: 1 * 100 µl

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Catalog Number: (BIRBORB131160-100)
Supplier: Biorbyt
Description: Anti-TNMD Rabbit Polyclonal Antibody (PE (Phycoerythrin)/Cy7®)
UOM: 1 * 100 µl

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Catalog Number: (BIRBORB130734-100)
Supplier: Biorbyt
Description: Anti-BAX Rabbit Polyclonal Antibody (PE (Phycoerythrin)/Cy7®)
UOM: 1 * 100 µl

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Catalog Number: (BIRBORB130710-100)
Supplier: Biorbyt
Description: Anti-SNCA Rabbit Polyclonal Antibody (PE (Phycoerythrin)/Cy7®)
UOM: 1 * 100 µl

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Catalog Number: (BIRBORB130783-100)
Supplier: Biorbyt
Description: Anti-TNFRSF8 Rabbit Polyclonal Antibody (PE (Phycoerythrin)/Cy7®)
UOM: 1 * 100 µl

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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