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Image Unavailable-PRSI34-137

Anti-MUC5AC Mouse Monoclonal Antibody [clone: SPM297]

Catalog Number: (PRSI34-137)
Supplier: ProSci Inc.
Description: This mAb recognises the peptide core of gastric mucin M1 (>1,000 kDa) (recently identified as Mucin 5AC). Its epitope is destroyed by beta-mercaptoethanol and proteases but not by periodate treatment. Antibody to gastric mucin M1 reacts with the gastric epithelium of normal human gastrointestinal tract as well as with the precancerous and cancerous colon but not with normal adult colon. It also reacts with fetal colonic mucosa. Resurgence of gastric mucin reactivity during colonic carcinogenesis is due to re-expression of the peptide core of gastric (or fetal colonic) mucins.
UOM: 1 * 100 µG
Product Image-113-8669

Safety device against suspension trauma, Miller Relief Step™ Safety Device

Catalog Number: (113-8669)
Supplier: HONEYWELL SAFETY
Description: The Miller Relief Step™ Safety Device alleviates the effects of orthostatic intolerance, also known as suspension trauma. If a fall occurs, a person becomes suspended in a harness and remains both vertical and sedentary for a period of time, causing blood to ‘pool’ in the veins of the legs. Subsequently, blood flow is restricted to the brain and other major organs that may initially result in unconsciousness. If not rescued promptly, serious injury or death may occur. The Miller Relief Step is designed to provide a short-term solution in preventing suspension trauma.
UOM: 1 * 1 items
Image Unavailable-PRSI92-306

Human recombinant Cyclin-H (from E. coli)

Catalog Number: (PRSI92-306)
Supplier: ProSci Inc.
Description: Human CCNH, also known as Cyclin-H，MO15-associated protein，p34 and p37, is a protein which belongs to the highly conserved cyclin family. Cyclin family members are characterised by a dramatic periodicity in protein abundance through the cell cycle. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1.CCNH regulates CDK7 which is the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. CCNH is also involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
UOM: 1 * 50 µG
Product Image-112-5413

Chemical resistant gloves, u-chem 3300

Supplier: UVEX
Description: These highly sensitive chemical protection gloves with gauntlet, made of seamless bamboo-viscose fibre and a nitrile rubber coating, are kind to skin and comfortable to wear even for long periods.

Product Image-613-7147

VWR® Ergonomic High Performance (EHP), Multi-Channel Pipettes, Mechanical, Variable Volume

Supplier: VWR Collection
Description: The ergonomic high performance pipettes from VWR® provide accuracy and precision you can rely on. The upgraded ergonomic features deliver comfortable pipetting even during extensive periods of use.

5 year warranty

Product Image-ST3028

Autoclaves, portable, electric

Catalog Number: (ST3028)
Supplier: DIXONS SURGICAL INSTR
Description: This range of portable autoclaves is designed for safety and reliability, yet remain easy to use and maintain. They are fitted with an automatic cut-out to prevent them boiling dry. The lid is removable for full width access, items can either be placed in the inner liner provided or in accessory dressing drums or basket. All models are heated with a 2 kW single internal element. Temperature is controlled by an electronic temperature controller and a PT100 thermocouple. After the sterilising period, a condensing vacuum is drawn to aid drying. This is particularly useful for dressings and drapes.
UOM: 1 * 1 items

Market Source Item This is a MarketSource item. Additional charges may apply

Product Image-PRSI27-213

Anti-CCNT1 Rabbit Polyclonal Antibody

Catalog Number: (PRSI27-213)
Supplier: ProSci Inc.
Description: CCNT1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
UOM: 1 * 50 µG
Product Image-705-0709

Thermoreactors, CR series

Supplier: WTW
Description: Thermoreactors for the determination of COD, total nitrogen or total phosphorus, ensure complete digestion of the sample and maintain the necessary high reaction temperature throughout the defined period. The most important temperatures and digestion times are stored in 8 fixed, easily selectable digestion programmes. CR 3200 and CR 4200 can be used with optional TFK CR external temperature probe, which can be used as a testing aid. It can be plugged into the interface in place of a cuvette, the set and actual temperatures can be output to either a printer or a PC, so function can not only be monitored, but also documented. Suitable for 16 mm cuvettes.

Product Image-PRSI48-321

Anti-MST1R Rabbit Polyclonal Antibody

Catalog Number: (PRSI48-321)
Supplier: ProSci Inc.
Description: MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers.
UOM: 1 * 50 µG
Product Image-PRSI7223

Anti-CCNT1 Rabbit Polyclonal Antibody

Catalog Number: (PRSI7223)
Supplier: ProSci Inc.
Description: CCNT1 Antibody: Cyclins function as regulators of CDK kinases and exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin-T1 protein (CCNT1) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. CCNT1 tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing CCNT1 and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. CCNT1 and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.
UOM: 1 * 100 µG
Product Image-PRSI55-521

Anti-CCNH Rabbit Polyclonal Antibody

Catalog Number: (PRSI55-521)
Supplier: ProSci Inc.
Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.
UOM: 1 * 400 µl
Product Image-734-0107

Cell Recovery Solution, Corning®

Catalog Number: (734-0107)
Supplier: Corning
Description: Corning® Cell Recovery Solution allows for the recovery of cells cultured on Corning® Matrigel® Basement Membrane Matrix for subsequent biochemical analysis. Corning® Cell Recovery Solution depolymerises Corning® Matrigel® Matrix gels without enzymatic digests and lengthy incubation periods at high temperatures. Cells are released without damage thereby avoiding biochemical changes during incubation and digestion of extracellular portions of cell-surface receptors and adhesion molecules.
UOM: 1 * 100 mL

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Product Image-PRSI3427

Anti-HA Rabbit Polyclonal Antibody

Catalog Number: (PRSI3427)
Supplier: ProSci Inc.
Description: Avian Influenza Hemagglutinin Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability.
UOM: 1 * 100 µG
Product Image-PRSI3911

Anti-HA 3 Goat Polyclonal Antibody

Catalog Number: (PRSI3911)
Supplier: ProSci Inc.
Description: Avian Influenza Hemagglutinin 3 Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability.
UOM: 1 * 100 µG
Product Image-PRSI3421

Anti-Avian Influenza Neuraminidase Rabbit Polyclonal Antibody

Catalog Number: (PRSI3421)
Supplier: ProSci Inc.
Description: Avian Influenza Neuraminidase Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. Novel influenza virus strains emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. Although it has been known that cleavage site and glycosylation patterns of the HA protein play important roles in determining the pathogenicity of H5 avian influenza viruses, it has only recently been shown that an additional glycosylation site within the globular head of the NA protein also contributes to the high virulence of the H5N1 virus.
UOM: 1 * 100 µG
Product Image-PRSI55-706

Anti-CCNH Rabbit Polyclonal Antibody

Catalog Number: (PRSI55-706)
Supplier: ProSci Inc.
Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.
UOM: 1 * 400 µl
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
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