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Image Unavailable-BOSSBS-9623R-CY7

Anti-PARP16 Rabbit Polyclonal Antibody (Cy7®)

Description: Poly(ADP-ribosylation) is a method of DNA damage-dependent posttranslational modification that helps to rescue injured proliferating cells from cell death. The PARP (poly(ADP-ribose) polymerase) proteins comprise a superfamily of enzymes that functionally modify histones and other nuclear proteins, thereby preventing cell death. PARPs use NAD+ as a substrate to catalytically transfer ADP-ribose residues onto protein acceptors; a process that, when repeated multiple times, leads to the formation of poly(ADPribose) chains on the protein. The presence of these chains alters the function of the target protein and promotes cell survival. PARP proteins are implicated in a variety of diseases, including cancer, neurodegenerative and inflammatory disorders. PARP-16 is a 322 amino acid poly (ADP-ribose) polymerase protein localized to the membrane. Expressed as three isoforms produced by alternative splicing, PARP-16 contains one PARP catalytic domain.
Catalog Number: BOSSBS-9623R-CY7
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-43896.03

Polyethyleneimine, M.W. 25,000, linear

Description: Polyethyleneimine, M.W. 25,000, linear
Catalog Number: 43896.03
UOM: 1 * 1 g
Supplier: Thermo Fisher Scientific

MSDS Certificates


Image Unavailable-APOSPC3329-5KG

PTFE

Description: 60 wt % dispersion in water; 0.05-0.5 micron particles.
Catalog Number: APOSPC3329-5KG
UOM: 1 * 5 kg
Supplier: Apollo Scientific
Image Unavailable-BOSSBS-9623R-FITC

Anti-PARP16 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Description: Poly(ADP-ribosylation) is a method of DNA damage-dependent posttranslational modification that helps to rescue injured proliferating cells from cell death. The PARP (poly(ADP-ribose) polymerase) proteins comprise a superfamily of enzymes that functionally modify histones and other nuclear proteins, thereby preventing cell death. PARPs use NAD+ as a substrate to catalytically transfer ADP-ribose residues onto protein acceptors; a process that, when repeated multiple times, leads to the formation of poly(ADPribose) chains on the protein. The presence of these chains alters the function of the target protein and promotes cell survival. PARP proteins are implicated in a variety of diseases, including cancer, neurodegenerative and inflammatory disorders. PARP-16 is a 322 amino acid poly (ADP-ribose) polymerase protein localized to the membrane. Expressed as three isoforms produced by alternative splicing, PARP-16 contains one PARP catalytic domain.
Catalog Number: BOSSBS-9623R-FITC
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-9623R-A555

Anti-PARP16 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Description: Poly(ADP-ribosylation) is a method of DNA damage-dependent posttranslational modification that helps to rescue injured proliferating cells from cell death. The PARP (poly(ADP-ribose) polymerase) proteins comprise a superfamily of enzymes that functionally modify histones and other nuclear proteins, thereby preventing cell death. PARPs use NAD+ as a substrate to catalytically transfer ADP-ribose residues onto protein acceptors; a process that, when repeated multiple times, leads to the formation of poly(ADPribose) chains on the protein. The presence of these chains alters the function of the target protein and promotes cell survival. PARP proteins are implicated in a variety of diseases, including cancer, neurodegenerative and inflammatory disorders. PARP-16 is a 322 amino acid poly (ADP-ribose) polymerase protein localized to the membrane. Expressed as three isoforms produced by alternative splicing, PARP-16 contains one PARP catalytic domain.
Catalog Number: BOSSBS-9623R-A555
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-13173R-FITC

Anti-FIP1L1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Description: The Component of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex plays an important role in the 3'-end formation of pre-mRNA. This complex recognizes the AAUAAA signal sequence and interacts with poly(A) polymerase to process and add to the poly(A) tail. FIP1L1 (FIP1-like 1), also known as Pre-mRNA 3'-end-processing factor FIP1, FIP1 (Factor interacting with PAP) and RHE (Rearranged in hypereosinophilia), is a 594 amino acid nuclear protein that is a component of the CPSF complex. Within the complex, FIP1L1 contributes to the poly(A) recognition and stimulates poly(A) addition. Fusion of the genes encoding FIP1L1 and PDGFRA due to an interstitial deletion on chromosome 4q12 is the cause of hypereosinophilia syndrome, a rare blood disorder characterized by continuous overproduction of eosinophils in the bone marrow that leads to tissue infiltration and organ damage. There are three isoforms of FIP1L1 that are produced as a result of alternative splicing events.
Catalog Number: BOSSBS-13173R-FITC
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-13173R-A488

Anti-FIP1L1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Description: The Component of the Cleavage and Polyadenylation Specificity Factor (CPSF) complex plays an important role in the 3'-end formation of pre-mRNA. This complex recognizes the AAUAAA signal sequence and interacts with poly(A) polymerase to process and add to the poly(A) tail. FIP1L1 (FIP1-like 1), also known as Pre-mRNA 3'-end-processing factor FIP1, FIP1 (Factor interacting with PAP) and RHE (Rearranged in hypereosinophilia), is a 594 amino acid nuclear protein that is a component of the CPSF complex. Within the complex, FIP1L1 contributes to the poly(A) recognition and stimulates poly(A) addition. Fusion of the genes encoding FIP1L1 and PDGFRA due to an interstitial deletion on chromosome 4q12 is the cause of hypereosinophilia syndrome, a rare blood disorder characterized by continuous overproduction of eosinophils in the bone marrow that leads to tissue infiltration and organ damage. There are three isoforms of FIP1L1 that are produced as a result of alternative splicing events.
Catalog Number: BOSSBS-13173R-A488
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-59005.

Pluronic® F-127 10% in water

Description: Ready-to-use solution of Pluronic® F-127, a nonionic detergent useful for solubilizing hydrophobic dye molecules such as AM esters of Fura-2, Fluo-3, Indo-1, or Rhod-2 to facilitate cell loading.
Catalog Number: 59005.
UOM: 1 * 30 mL
Supplier: Biotium
Image Unavailable-BOSSBS-13018R-A555

Anti-POLI Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Description: DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol Ω, which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.
Catalog Number: BOSSBS-13018R-A555
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-13018R-FITC

Anti-POLI Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Description: DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol Ω, which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.
Catalog Number: BOSSBS-13018R-FITC
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-9623R-CY3

Anti-PARP16 Rabbit Polyclonal Antibody (Cy3®)

Description: Poly(ADP-ribosylation) is a method of DNA damage-dependent posttranslational modification that helps to rescue injured proliferating cells from cell death. The PARP (poly(ADP-ribose) polymerase) proteins comprise a superfamily of enzymes that functionally modify histones and other nuclear proteins, thereby preventing cell death. PARPs use NAD+ as a substrate to catalytically transfer ADP-ribose residues onto protein acceptors; a process that, when repeated multiple times, leads to the formation of poly(ADPribose) chains on the protein. The presence of these chains alters the function of the target protein and promotes cell survival. PARP proteins are implicated in a variety of diseases, including cancer, neurodegenerative and inflammatory disorders. PARP-16 is a 322 amino acid poly (ADP-ribose) polymerase protein localized to the membrane. Expressed as three isoforms produced by alternative splicing, PARP-16 contains one PARP catalytic domain.
Catalog Number: BOSSBS-9623R-CY3
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-9623R-A488

Anti-PARP16 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Description: Poly(ADP-ribosylation) is a method of DNA damage-dependent posttranslational modification that helps to rescue injured proliferating cells from cell death. The PARP (poly(ADP-ribose) polymerase) proteins comprise a superfamily of enzymes that functionally modify histones and other nuclear proteins, thereby preventing cell death. PARPs use NAD+ as a substrate to catalytically transfer ADP-ribose residues onto protein acceptors; a process that, when repeated multiple times, leads to the formation of poly(ADPribose) chains on the protein. The presence of these chains alters the function of the target protein and promotes cell survival. PARP proteins are implicated in a variety of diseases, including cancer, neurodegenerative and inflammatory disorders. PARP-16 is a 322 amino acid poly (ADP-ribose) polymerase protein localized to the membrane. Expressed as three isoforms produced by alternative splicing, PARP-16 contains one PARP catalytic domain.
Catalog Number: BOSSBS-9623R-A488
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-J62679.27

Pyridoxamine dihydrochloride cell culture reagent

Description: Pyridoxamine dihydrochloride cell culture reagent
Catalog Number: J62679.27
UOM: 1 * 2,5 g
Supplier: Thermo Fisher Scientific

MSDS Certificates


Image Unavailable-8.43866.1000

Polyvinyl alcohol, M.W. ∼ 60000 for synthesis, fully hydrolysed, Sigma-Aldrich®

Description: Polyvinyl alcohol, M.W. ∼ 60000 for synthesis, fully hydrolysed, Sigma-Aldrich®
Catalog Number: 8.43866.1000
UOM: 1 * 1 kg
Supplier: Merck

MSDS


Product Image-BOSSBS-13018R

Anti-POLI Rabbit Polyclonal Antibody

Description: DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol Ω, which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.
Catalog Number: BOSSBS-13018R
UOM: 1 * 100 µl
Supplier: Bioss
Image Unavailable-BOSSBS-9435R-CY5.5

Anti-PAPOL A+B+G Rabbit Polyclonal Antibody (Cy5.5®)

Description: Polyadenylation of the 3-prime ends of eukaryotic mRNAs is a key event that takes place in the nucleus during maturation of mRNA. The reaction includes endoribonucleolytic cleavage of the pre-RNA at the poly(A) site that leads to synthesis of the poly(A) tail at the 3-prime end of the upstream cleavage product. The poly(A) polymerase (PAP) is required The adenosine addition reaction depends on poly(A) polymerase (PAP) activity. The testis express PAP-beta (TPAP) in the cytoplasm of spermatogenic cells. The adenosine addition function of PAP-beta plays a critical role in male germ cell production. PAP-beta-deficient transgenic mice display impaired expression of haploid-specific genes that are necessary for spermatogenesis. The intronless gene encoding human PAP-beta maps to chromosome 7p22.3.
Catalog Number: BOSSBS-9435R-CY5.5
UOM: 1 * 100 µl
Supplier: Bioss
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