You Searched For: Pyrimethamine


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Supplier: Thermo Scientific
Description: Pyrimethamine 98%

Catalog Number: (46706-250MG)
Supplier: Merck
Description: Organic Standard, Pyrimethamine
UOM: 1 * 250 mg

Catalog Number: (1589007.)
Supplier: USP
Description: USP Reference Standards are specified for use in conducting official USP–NF tests and assays. USP also provides Reference Standards specified in the Food Chemicals Codex as well as authentic substances—high-quality chemical samples—as a service to analytical, clinical, pharmaceutical and research laboratories. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.
UOM: 1 * 200 mg


Supplier: MP Biomedicals
Description: Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate has been reported to arrest the cell cycle in late G1/S thus leading to the inhibition of the synthesis of DNA, RNA, thymidylates, and proteins. The main mechanism of action is reported to involve the inhibition of enzymes involved in purine metabolism which leads to the accumulation of adenosine or the suppression of intercellular adhesion molecule expression by T cells. Additionally, this compound has been observed to inhibit DHFR.
Methotrexate is used for chemotherapy either alone or in combination with other agents. It is effective for the treatment of a number of cancers including: breast, head and neck, leukemia, lymphoma, lung, osteosarcoma, bladder, and trophoblastic neoplasms. It is also used in treatment of autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It is used to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.
Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis.

Catalog Number: (PHR3231-500MG)
Supplier: Merck
Description: Pyrimethamine pharmaceutical secondary standard, certified reference material 1 * 500 mg
UOM: 1 * 500 mg


Catalog Number: (CAYM16472-10)
Supplier: Cayman Chemical
Description: Pyrimethamine? 1 * 10 mg
UOM: 1 * 10 mg


Catalog Number: (CAYM16472-50)
Supplier: Cayman Chemical
Description: Pyrimethamine? 1 * 50 mg
UOM: 1 * 50 mg


Catalog Number: (CAYM16472-500)
Supplier: Cayman Chemical
Description: Pyrimethamine? 1 * 500 mg
UOM: 1 * 500 mg


Catalog Number: (CAYM16472-100)
Supplier: Cayman Chemical
Description: Pyrimethamine? 1 * 100 mg
UOM: 1 * 100 mg


Catalog Number: (PROOMM1630.00)
Supplier: LGC Standards PROMOCHEM
Description: PYRIMETHAMINE 1 * 250 mg
UOM: 1 * 250 mg


Catalog Number: (ICNA0219418005)
Supplier: MP Biomedicals
Description: PYRIMETHAMINE. Antiprotozoal compound.For Research Use Only 1 * 5 g
UOM: 1 * 5 g


Catalog Number: (PROOLGCFOR1630.00)
Supplier: LGC Standards PROMOCHEM
Description: PYRIMETHAMINE 1 * 10 mg
UOM: 1 * 10 mg


Catalog Number: (ICNA0219418001)
Supplier: MP Biomedicals
Description: PYRIMETHAMINE. Antiprotozoal compound. For Research Use Only 1 * 1 g
UOM: 1 * 1 g


Catalog Number: (ICNA0219418025)
Supplier: MP Biomedicals
Description: PYRIMETHAMINE. Antiprotozoal compound.For Research Use Only 1 * 25 g
UOM: 1 * 25 g


Supplier: MP Biomedicals
Description: Folic Acid antagonist; structurally similar to folic acid. Methotrexate is a mixture of 4-amino-10-methylfolic acid and closely related compounds.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us on +353 1 88 22222.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at eurega_services@eu.vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organisation. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
Product(s) marked with this symbol are discontinued - sold till end of stock. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service on +353 1 8822222.
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